骨瓜提取物对活动期类风湿性关节炎的疗效和安全性临床分析  

Clinical analysis of the efficacy and safety of Gugua extracts on active stage rheumatoid arthritis

作　　者：董卫芹 沈洁 吴英 郭良君 孔飞飞 

机构地区：[1]解放军第九八医院骨三科,浙江湖州313000 [2]解放军第九八医院骨六科,浙江湖州313000 [3]放军第九八医院药械科,浙江湖州313000

出　　处：《中国现代医生》2017年第2期23-26,共4页China Modern Doctor

基　　金：浙江省药学会医院药学专项科研基金项目(2012ZYY24)

摘　　要：目的综合分析骨瓜提取物对活动期类风湿性关节炎的疗效和安全性,为治疗活动期类风湿性关节炎患者提供科学的数据参考。方法选取2015年4月~2016年4月我院收治的90例活动期类风湿性关节炎患者的临床资料作为研究对象,按照入院顺序随机分为实验组与对照组,每组45例。对照组应用常规治疗方法,实验组在对照组基础上应用骨瓜提取物注射液治疗。分析比较两组患者的临床治疗总有效率及治疗前后C反应蛋白水平、类风湿因子水平、红细胞沉降率水平、视觉模拟疼痛评分、晨僵时间、血常规(白细胞计数、红细胞计数)、肝肾功能(丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血肌酐、尿素氮)、不良反应发生率等参数指标。结果 1治疗前,两组患者C反应蛋白水平、类风湿因子水平、红细胞沉降率水平、视觉模拟疼痛评分、晨僵时间、血常规、肝肾功能等比较,差异无统计学意义(P>0.05);治疗后,实验组C反应蛋白水平、类风湿因子水平、红细胞沉降率水平、视觉模拟疼痛评分、晨僵时间、血常规、肝肾功能等显著优于对照组(P<0.05);2实验组治疗总有效率高于对照组(P<0.05);3实验组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论骨瓜提取物对活动期类风湿性关节炎的疗效和安全性较高。Objective To comprehensively analyze the curative effect and safety of Gugua extract on active stage rheumatoid arthritis（RA）, and to provide scientific data for the treatment, of active stage rheumatoid arthritis （RA）. Methods Clinical data of 90 patients with active stage rheumatoid arthritis who were admitted to our hospital from April 2015 to April 2016 were selected as the research Subjects. According to the order of admission, the patients were randomly divided into the experimental group and the control group, with 45 cases in each group, The control group was treated with routine therapy, and the experimental group was treated with the injection of gugua extract on the basis of the control group. The total effective rate of clinical treatment and the levels of C-reactive protein before the treatment, rheumatoid factor level, erythrocyte sedimentation rate, visual analogue pain score, morning stiffftess time, blood routine（white blood cell count, red blood cell count）, liver and kidney function （alanine aminotransferase, aspar- rate aminotransferase, serum creatinine, urea nitrogen）, adverse reaction rates and other parameters in both groups were analyzed. Results ①There were no significant differences in C-reactive protein level, rheumatoid factor level, erythro- cyte sedimentation rate, visual analogue pain score, morning stiffness time, blood routine, liver and kidney function be- tween the two groups before treatment（P〉0.05）; after treatment, the levels of C-~reactive protein, rheumatoid factor, ery- throcyte sedimentation rate, visual analogue pain score, morning stiffness, blood routine, [irer and kidney function in the experimental group were significantly higher than those in the control group（P〈O.05）; ②The total effective rate in the experimental＇ group was much higher than that in the control group （P〈0.05）; ③the incidence rate of adverse reae tions in the experimental group was not statistically significant compared with that in the control group（P〉0

关 键 词：骨瓜提取物 活动期类风湿性关节炎 总有效率 安全性 

分 类 号：R593.22[医药卫生—内科学]