艰难梭菌相关性腹泻中医诊治规律文献分析  

Diagnosis and prescription laws in treating Clostridium difficile-associated diarrhea by traditional Chinese medicine and the literature analysis

作　　者：刘欣竹[1] 王君[2] 郭亚楠[2] LIU Xinzhu WANG Jun GUO Yanan(Department of Pediatrics, ChinaJapan Friendship Hospital, Beijing 100029, China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院儿科

出　　处：《中国中西医结合儿科学》2017年第1期9-15,共7页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：十二五国家科技支撑计划项目(2012BAI03B02)

摘　　要：目的探讨和研究艰难梭菌相关性腹泻(CDAD)中医诊治用药规律,为临床治疗CDAD提供参考。方法以计算机检索知网、万方等数据库,收集近10年有关中医或者中西医结合治疗CDAD相关的临床随机对照研究。对其治疗情况按治则治法、单味药使用频次、功效、药性、药味、归经进行统计分析。结果前三位的治法为健脾、益气、渗湿,占52%。补气健脾用药多选用白术、甘草、党参、山药、白扁豆;利水渗湿用药多选用茯苓、薏苡仁;化湿用药选砂仁、苍术。补虚药、利水渗湿药、化湿药为使用频率较多的药物,占使用率的53.6%。性温、平的药物占65.7%,为治疗CDAD的主导药物。甘、苦两类药味占59.5%,表明中药治疗CDAD以甘、苦味药为主。归脾、胃、肺经的药物占总频率的60.4%。结论 CDAD的主要治疗原则是健脾益气、渗湿。遣方用药宜选用药性以温、平,药味以甘、苦为主,药物归经以归脾、胃、肺三经的为主。Objective To explore and study the diagnosis and prescription laws in treating Clostridium difficile-associated diarrhea by traditional Chinese medicine,in order to provide reference for clinical treatment of CDAD.Methods We searched CNKI,WanFang,and other databases,literatures of both traditional Chinese medicine and integrated traditional Chinese and Western medicine in treating CDAD,which were published in the past 10 years,were collated and analyzed.We conducted statistical analysis of the therapeutic principle,frequency of use,efficacy,potency and taste of a single herb.Results The top three treatment were related to strengthening spleen,invigorating Qi and removing dampness,accounting for52%.Atractylodes,licorice,codonopsis,Chinese yam and white beans were chosen to strengthen spleen and invigorating Qi;Poria cocos and coix seeds were chosen to induce diuresis and eliminate dampness;Fructus amomi and herb were chosen to remove dampness.In treating CDAD,drugs to strengthen spleen,induce diuresis and eliminate dampness were more frequently used,accounting for 53.6%.From the point of view of drug potency,warm and flat drugs accounted for 65.7%.As for the smell and taste,sweet and bitter drugs accounted for 59.5%.In summary,drugs associated with treating spleen,stomach and lung accounted for 60.4% of all drugs used in treating CDAD.Conclusion The main principle of treatment for CDAD is to strengthen spleen,invigorate Qi and remove dampness.Herbal prescription should focus on warm and flat herbs,with sweet and bitter smell to go through the spleen,stomach and lung.

关 键 词：艰难梭菌相关性腹泻 中药 诊断 治疗 儿童 

分 类 号：R725.7[医药卫生—儿科]