纳米微针对人皮肤屏障功能及红斑的影响  

Effects of Nanochip Treatment on Skin Barrier Function and Erythema

作　　者：陶艳玲[1] 苗颖颖 吴婷妍 刘娟[1] 许阳[1] 徐百 骆丹[1] 周炳荣[1] Tao Yanling Miao Yingying Wu Tingyan Liu Juan Xu Yang Xu Bai Luo Dan Zhou Bingrong(The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Suzhou Nanomed Skincare Inc, Suzhou 215000, China)

机构地区：[1]南京医科大学第一附属医院,南京210029 [2]苏州纳通生物纳米技术有限公司,苏州215000

出　　处：《中国中西医结合皮肤性病学杂志》2017年第1期11-15,共5页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的研究纳米微针处理对面部皮肤屏障功能及红斑的影响。方法募集16例临床受试者,随机分为2组,每组8例。1组受试者随机一侧面颊部使用针长为0.25 mm的纳米微针处理6遍,另一侧使用针长为0.25 mm的传统微针处理6遍;另1组受试者随机一侧面颊部使用针长为0.5 mm的纳米微针处理6遍,另一侧使用针长为0.5mm的传统微针处理6遍。在处理前、处理后即刻、处理后4、8、24、48、72 h分别检测经皮水分丢失(Trans-epidermal water loss,TEWL)、角质层含水量及红斑量。结果经针长为0.25 mm的纳米微针和传统微针处理后,两侧面颊部TEWL、角质层含水量和红斑量数值均无显著性差异。针长为0.5 mm的纳米微针和传统微针处理后,在处理后即刻、4、8、24 h时点上,纳米微针侧TEWL数值显著低于传统微针侧;在处理后8 h时点上,纳米微针侧红斑量数值显著低于普通微针侧。不同针长的纳米微针在处理后4~8 h内TEWL、角质层含水量、红斑量均能恢复至基线水平。而传统微针侧,皮肤处理后48~72 h内TEWL、角质层含水量、红斑量才能恢复至基线水平。结论与相同针长的传统微针治疗相比,纳米微针处理后对皮肤屏障功能的影响较小,并且恢复更快。Objective In order to determine the degree of acute skin damage and the time required for the recovery of facial skin barrier function after the skin was treated with microneedles and nanochips of various tip lengths. Methods For this split face comparative study, a total of 16 subjects were enrolled and radomly divided into 2 groups. In the first group, one of the facial sides of each subject was treated with 0.25 mm long nanotips for 6 times while the other facial side was treated with0.25 mm traditional microneedles with a straight blade for 6 times. In the second group, one of the facial side was treated with0.5 mm nanotips for 6 times while the other facial side was treated with 0.5 mm traditional micro-needles with a straight blade for 6 times. Evaluations for trans-epidermal water loss（TEWL）, skin hydration and erythema were carried out at baseline, 0,4, 8, 24, 48 and 72 hours after the treatment. Results There was no significant difference in TEWL, skin hydration and erythema between the two facial sides of the subjects in group one who were treated with 0.25 mm nanochips and traditional micro-needles. However in the subjects of group two, the mean TEWL of the facial side treated with 0.5 mm nanochips was relatively lower than that of the 0.5 mm traditional micro-needles treated facial side at 0, 4, 8 and 24 hours after the treatment.Mean erythema of the facial side treated with 0.5 mm nanochips micro-needles was also relatively lower than that of the 0.5mm traditional micro-needles treated facial side at 8 hours after the treatment. Rapid recovery of skin barrier function was observed within 4 to 8 hours after treatment with various lengths of nanochips while it took at least 48 to 72 hours for recovery of skin barrier function after treatment with various lengths of traditional micro-needles as measured by TEWL. Conclusion The skin disruption caused by nanotips treatment recovers quicker than the traditional microneedle treatment at equal lengthes.

关 键 词：纳米微针 皮肤屏障 经皮水分丢失 红斑 角质层含水量 

分 类 号：R751[医药卫生—皮肤病学与性病学]