瑞舒伐他汀与胃饥饿素对糖脂代谢异常大鼠作用比较  

Effect of rovastatin and ghrelin on metabolism of blood glucose and blood lipids in rats

作　　者：张曼[1] 王实[1] 佟浩[2] 孙晓[3] ZHANG Man WANG shi TONG Hao et al(Department of Cardiology ,Affiliated Central Hospital of Shen yang Medical College, Shenyang 110024, Liaoning Province, China)

机构地区：[1]沈阳医学院附属中心医院循环内科,110024 [2]中国医科大学解剖教研室 [3]沈阳市妇婴医院循环内科

出　　处：《中华老年心脑血管病杂志》2017年第3期305-307,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：辽宁省自然科学基金(20102220);沈阳市科技计划项目(F12-277-1-22;F13-221-9-14);辽宁省"百千万人才工程"资助项目(2014-322);辽宁省高层次人才资助项目(2014921004)

摘　　要：目的观察瑞舒伐他汀与胃饥饿素对糖脂代谢异常模型大鼠血糖、血脂、体质量及血管内皮细胞间黏附分子1(ICAM-1)、血管细胞黏附分子1(VCAM-1)的作用。方法选择健康雄性无特定病原体级Wistar大鼠40只,高脂饮食20d,随机取10只作为对照组,其余大鼠链脲佐菌素诱导糖尿病,造模成功后,随机分为3组,模型组、瑞舒伐他汀组、胃饥饿素组,每组10只。各组大鼠继续给予高脂饮食12周后检测血脂、血糖、体质量和高敏C反应蛋白(hs-CRP)水平,Western blot法检测血管内皮组织中ICAM-1、VCAM-1蛋白表达。结果与对照组比较,模型组体质量、血糖、LDL-C、TC、hs-CRP、ICAM-1、VCAM-1明显增加,瑞舒伐他汀组体质量、血糖、LDL-C、hs-CRP、ICAM-1、VCAM-1明显增加,胃饥饿素组血糖、LDL-C、ICAM-1、VCAM-1明显增加(P<0.05,P<0.01)。与瑞舒伐他汀组比较,胃饥饿素组血糖、体质量明显降低[(9.89±6.32)mmol/L vs(17.56±3.56)mmol/L,(289.62±32.66)g vs(358.72±30.89)g,P<0.01]。结论胃饥饿素不仅调脂、抗炎作用与瑞舒伐他汀相似,而且降糖、降体质量作用优于瑞舒伐他汀。Objective To study the effect of rovastatin and ghrelin on blood glucose,blood lipids,BMI,ICAM-1and VCAM-1in rat model of abnormal blood glucose and blood lipids metabolism.Methods Forty healthy male Wistar rats were randomly divided into control group,model group,rovastatin treatment group and ghrelin treatment group（10in each group）.After the animals were fed with a high-fat diet for 12 weeks,their serum blood lipids,blood glucose,hs-CRP levels and BMI were measured.Expressions of ICAM-1and VCAM-1were detected by Western blot.Results The BMI,serum blood glucose,LDL-C,TC,hs-CRP levels,ICAM-1and VCAM-1expression levels were significantly higher in model group,rovastatin treatment group and ghrelin treatment group than in control group（P〈0.05,P〈0.01）.However,the serum blood glucose level and BMI were significantly lower in ghrelin treatment group than in rovastatin treatment group（9.89±6.32mmol/L vs 17.56±3.56mmol/L,289.62±32.66 g vs 358.72±30.89 g,P〈0.01）.Conclusion The effect of ghrelin on blood lipids and inflammation is similar with that of rovastatin and is better than that of rovastatin on blood glucose and BMI.

关 键 词：细胞黏附分子 血管细胞黏附分子1 糖尿病 胃促生长素 降血脂药 

分 类 号：R965[医药卫生—药理学]