肺癌化疗患者医院感染病原学特征研究  

Research on etiological feature of hospital infection with lung cancer chemotherapy patients

作　　者：李桃[1] 张晓东[1] 龚光明[1] 徐俊炜[1] 

机构地区：[1]江苏省南通市肿瘤医院,江苏南通226361

出　　处：《中国消毒学杂志》2017年第2期136-139,共4页Chinese Journal of Disinfection

基　　金：江苏省南通市科技计划项目(HS2012062)

摘　　要：目的研究住院肺癌化疗患者医院感染病原学特征及相关危险因素,为有效防控提供科学依据。方法通过前瞻性研究方法,对某肿瘤医院内科住院肺癌化疗患者医院感染与感染病原菌特征进行观察,分析相关危险因素。结果该医院肿瘤内科共纳入肺癌化疗患者1 530例,发生医院感染56例,感染率3.66%。从56例感染患者送检标本中共分离病原菌74株,其中革兰阴性菌45株、革兰阳性菌16株和真菌13株。除真菌之外,所分离的病原菌均普遍耐药,尚未检出耐碳青霉烯类和耐万古霉素菌株。多因素分析显示,住院时间≥14 d、化疗周期≥2周和大量预防性使用抗菌药物等构成肺癌化疗患者医院感染的独立危险因素。结论肺癌化疗患者医院感染病原菌以革兰阴性菌为主,且耐药情况严重,缩短化疗周期和严格抗菌药物使用为主要防控措施。Objective To study etiological feature of hospital infection and risk factors with lung cancer chemotherapy patients,to provide a scientific basis for effective prevention. Methods Prospective investigation was used to observe the etiological feature of patients with nosocomial infection after lung cancer chemotherapy from medical oncology,analyze risk factors. Results 56 cases from 1 530 patients with nosocomial infection after lung cancer chemotherapy occurred in hospital,the infection rate was 3. 66%. 74 strains of pathogens were isolated,45 strairs were Gram- negative bacteria,16 strairs were Gram- positive bacteria,13 strairs were fungi. Mainly bacteria were resisted to antibiotics except Carbapenems and vancomycin. Multivariate logistic regression analysis showed that hospitalization≥14 d,chemotherapy cycles≥2 weeks,the use of preventive antimicrobial drugs were independent risk factor causing nosocomial infection（ P 〈0. 05）. Conclusion Lung cancer chemotherapy patients with nosocomial infection pathogens is Gram- negative bacteria mainly. Infection is closely related to a variety of factors,clinical should develop targeted prevention and treatment measures to control hospital infection.

关 键 词：肺癌化疗 医院感染 病原学特征 危险因素 

分 类 号：R378[医药卫生—病原生物学]