子宫内膜异位症痛敏机制与脊髓电刺激治疗  

The research advances on mechanisms underlying endometriosis-associated hyperalgesia

作　　者：利雪阳 张美娟[2] 王云[1] 谢芳[1] 

机构地区：[1]首都医科大学附属北京朝阳医院麻醉科,100020 [2]首都医科大学附属北京同仁医院麻醉科,100005

出　　处：《国际麻醉学与复苏杂志》2017年第2期171-174,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（30801073）;北京市卫生系统高层次卫生人才（学科骨干）培养计划

摘　　要：背景子宫内膜异位症（endometriosis，EMT）是育龄期妇女最常见的疾病之一，慢性顽固性疼痛是其最主要的临床症状，近年来研究发现EMT疼痛合并有明显的神经系统变化。目的综述EMT疼痛的神经机制。内容综述EMT疼痛的动物模型及特点、外周及中枢敏化机制以及脊髓电刺激（spinal cord stimulation, SCS）对EMT疼痛的治疗效应。趋向阐明EMT痛敏机制，可望为该病的疼痛管理提供新方法。Background Endometriosis （EMT） is one of the most common diseases in women of reproductive age, whose predominant clinical symptom is intractable chronic pain. Recent studies indicate that EMT-associated pain is related to significant changes in the nervous system. Objective To review the neural mechanisms underlying EMT-associated pain. Content To review the animal models and characteristics of EMT-associated pain, mechanisms of peripheral and central sensitization, and the effect of spinal cord stimulation （SCS） on the treatment of EMT-associated pain. Trend To illuminate the mechanisms underlying EMT-associated hyperalgesia may provide a new viable method for the management of EMT-associated pain.

关 键 词：子宫内膜异位症 外周敏化 中枢敏化 

分 类 号：R711.71[医药卫生—妇产科学]