人参皂苷Rg_1微乳的制备及其表征  

Preparation and Quality Evaluation of Ginsenoside Rg_1 Microemulsion

作　　者：朱婉玲[1] 杨瑞[2] 唐思[2] 张世良[2] 董晓茜[2] 靖博宇[2] 夏素霞[2] 王静[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省中医药研究院临床药理实验室,辽宁沈阳110034

出　　处：《中华中医药学刊》2017年第3期576-578,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81303225)

摘　　要：目的:制备人参皂苷Rg_1微乳剂,并对其理化性质进行考察。方法:选择适宜的油相、表面活性剂和助表面活性剂,利用伪三元相图筛选微乳处方,研制出适合经口给药的微乳制剂并对其进行表征。结果:所制备的人参皂苷Rg_1微乳剂为无色澄清、透明均一的溶液。最优处方为油酸乙酯:HS 15∶乙醇∶5%葡萄糖溶液=12.5∶33.0∶11.0∶43.5。结论:通过优化处方制备的人参皂苷Rg_1微乳理化性质稳定,载药量提高。Objective ： To prepare ginsenoside Rg1 microemulsion and investigate its physical and chemical properties. Methods：The oil phase, surfactant and co -surfaetants were selected and the microemulsion formulation was prepared by the phase diagram of pseudo three phase diagram. A microemulsion formulation suitable for oral administration was devel- oped and its characterization was carried out. Results： A colorless, transparent and homogeneous solution were obtained by ginsenoside Rglmicroemulsion and optimal formulation was acetate： HS 15： ethanol： 5% glucose solution = 12.5 ： 33.0：11.0 ： 43.5. Conclusion： The physieoehemical properties of ginsenoside Rg1 mieroemulsion prepared were stable and the amount of drug loading was improved by the optimized formulation.

关 键 词：人参皂苷RG1 乳剂 伪三元相图 表征 

分 类 号：R284.1[医药卫生—中药学]