我院361例儿童药品不良反应报告分析  

Retrospective Analysis of 361 Cases of Children ADR Reports in Our Hospital

作　　者：王绚[1] 徐进[1] 许静[1] Wang Xuan Xu Jin Xu Jing(Children＇ s Hospital of Nanfing Medical University, Jiangsu Nanjing 210008, China)

机构地区：[1]南京医科大学附属儿童医院,江苏南京210008

出　　处：《儿科药学杂志》2017年第3期39-42,共4页Journal of Pediatric Pharmacy

基　　金：南京医科大学科技发展基金面上项目;编号2015NJMU068

摘　　要：目的:了解我院儿童药品不良反应(ADR)的发生情况及特点,为临床合理用药及药品安全性评价提供参考。方法:采用回顾性研究方法,对我院2014年上报至国家药品不良反应监测中心的361例ADR报告进行分析和归纳。结果:361例ADR主要集中在6岁以下患儿(68.98%);涉及16类药品、96个品种,主要为抗感染药物(60.11%),其次为中药(13.02%)、抗肿瘤药物(5.26%);给药途径主要为静脉给药(85.32%);临床表现主要为皮肤及其附件损害(73.96%),其次为全身性损害;医师和药师为ADR报告的主体,ADR类型主要为一般ADR(98.61%)。结论:应重点加强儿童群体ADR的监测,关注儿童专科用药ADR,强化临床药学监护,以促进临床安全合理用药。Objective： To investigate the regularity and characteristics of adverse drug reactions（ ADR） occurred in children,in an attempt to provide reference for rational drug use and safety evaluation. Methods： A total of 361 ADR reports of 2014 in our hospital were analyzed and summarized by using retrospective study method. Results： Of the total 361 ADR cases,children below 6 years old occurred most. There were 96 types of drugs,85.32% were induced by intravenous dripping which was the main ADR-inducing route of administration. In the ADR-involving drugs,anti-infective drugs（ 60.11%） were the most,traditional Chinese medicine and anti-tumor agents accouted for 13.02% and 5. 26% respectively. The lesion of skin and its appendants accounted for 73. 96%,and the next was systemic damage. The most types of ADR was general ADR,accounted for 98.16%. Conclusion： Great importance should be attached to enhance specialty ADR monitoring in children,so as to promote the clinical rational drug use and ensure medication safety.

关 键 词：药品不良反应 合理用药 儿童 监测 

分 类 号：R969.3[医药卫生—药理学]