吗啡耐受机制研究新进展  

New Progress in Research on Morphine Tolerance Mechanism

作　　者：宋扬[1] 赵昱[2] 李轶聪[2] 曾凡荣[3] 

机构地区：[1]佳木斯大学临床医学院,黑龙江佳木斯154000 [2]解放军第211医院,哈尔滨150080 [3]佳木斯大学附属第一医院,黑龙江佳木斯154002

出　　处：《微量元素与健康研究》2017年第2期71-74,共4页Studies of Trace Elements and Health

摘　　要：吗啡作为阿片受体激动剂在疼痛治疗中广泛应用,但吗啡长期应用可以导致药物耐受,这使得吗啡在临床上应用受到了一定的限制。研究发现胶质细胞激活参与吗啡耐受发生与发展。趋化因子作为神经元和胶质细胞相互调控的介质参与神经病理性疼痛的调节,而吗啡耐受与神经病理性疼痛有许多共同机制,因此趋化因子在吗啡耐受机制的作用引起了学者更多的关注。就吗啡耐受机制研究的新进展作一综述。Morphine,as an opioid receptor activator,is usually used for treating pain; however,long-term use of morphine will lead to tolerance,which restricts theapplication of morphine in clinical practice.It is discovered that glialcells activate and participate in the occurrence and development of morphine tolerance.Chemotactic factor,as the media regulating and controlling neurons anglial cells,participates in the adjustment inneuropathic pain; As morphine tolerance and neuropathic pain have many common mechanisms,the role of chemotacticfactor in the mechanism of morphine tolerance,as a result,has drawn more attention from scholars.The new progress in research on morphinetolerance mechanism is review in this paper.

关 键 词：吗啡耐受 胶质细胞 趋化因子 

分 类 号：R971[医药卫生—药品]