小儿温里止泻贴的提取和成型工艺优选  

Optimization of Extraction and Molding Process of Xiao'er Wenli Zhixie Plaster

作　　者：邱丽丽[1,2] 丁菊英[1] 杜茂波[3] 

机构地区：[1]胜利油田中心医院,山东东营257034 [2]山东中医药大学,济南250355 [3]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2017年第5期32-36,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:优选小儿温里止泻贴超临界CO_2提取工艺及基质配方,为该制剂的后续研究与开发提供参考。方法:选用L9(34)正交试验设计,以桂皮醛提取量为指标,考察萃取温度、压力、时间及CO_2流量对小儿温里止泻贴超临界CO_2流体萃取工艺的影响。以初粘性、剥离强度及内聚力为综合评价指标,通过响应面法考察聚乙烯醇、聚丙烯酸钠、甘油及羧甲基纤维素钠的用量,确定最佳基质配方。通过均匀度试验考察小儿温里止泻流浸膏与空白基质相容后的均匀度。结果:小儿温里止泻贴的最佳提取工艺为温度45℃,压力50 MPa,时间2.5 h,流量20 kg·h^(-1);桂皮醛提取量1.688 mg·g^(-1)。空白基质的最佳配方为聚乙烯醇-聚丙烯酸钠-甘油-羧甲基纤维素钠(0.6∶2.5∶1.0∶1.0)。该配方具有较好的初粘性、剥离强度、内聚力,均匀度为15,符合《中国药典》2015年版的规定。结论:优选的小儿温里止泻贴超临界CO_2流体萃取工艺稳定可行;优选的小儿温里止泻贴基质配方简单、稳定,可推广于大生产应用。Objective ： To optimize the extraction process of Xiao＇er Wenli Zhixie plaster by supercritical CO2 fluid extraction technology and its matrix prescription. Method： Extracting amount of cinnamaldehydc was selected as the indictor, L9 （34） orthogonal test was used to optimize supercritical CO2 fluid extraction technology of Xiao＇er Wenli Zhixie plaster. Initial viscosity, peel strength and cohesive strength were selected as indictors, L9 （34） orthogonal test was used to optimize matrix prescription. The uniformity of Xiao＇er Wenli Zhixie plaster was investigated by the uniformity test. Result： Optimum extraction parameters were as follows： extraction temperature at 45 ℃ , extraction pressure of 50 MPa, extraction time of 2.5 h, flow rate of CO2 of 20 kg·h^-1 Optimum matrix prescription was as follow： polyvinyl alcohol-sodium polyacrylate-glycerol-carboxy methyl cellulose sodium （0.6 ： 2.5 ： 1.0 ： 1.0）. This prescription showed satisfactory performance of initial viscosity, peel strength and cohesive strength; its uniformity was 15, which was in line with regulation in the 2015 edition of Chinese Pharmacopoeia. Conclusion： The optimized extraction process is stable and available. The optimum matrix prescription of is simple and stable, which can be applied to industrial production of Xiao＇er Wenli Zhixie plaster.

关 键 词：小儿温里止泻贴 基质配方 聚乙烯醇 聚丙烯酸钠 甘油 羧甲基纤维素钠 桂皮醛 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]