基于网络药理学的“金银花-连翘”药对作用机制分析  

Mechanism of Lonicerae Japonicae Flos-Weeping Forsythia Herbal Pair Based on Network Pharmacology

作　　者：吴嘉瑞[1] 金燕萍[1] 王凯欢 刘鑫馗 张丹[1] 张冰[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国实验方剂学杂志》2017年第5期179-183,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81473547);北京市中医药科技基金项目(JJ-2010-70);北京中医药大学科研创新团队项目(2011-CXTD-14)

摘　　要：目的:探讨"金银花-连翘"药对的功效物质基础和配伍机制。方法:从中药系统药理学分析平台(TCMSP)中寻找与金银花及连翘相关的所有化学成分,并寻找与其相关的潜在靶点,采用网络药理学的方法对金银花-连翘的功效物质和配伍机制进行研究。结果:通过口服利用度(OB),类药性(DL)条件筛选得出16个候选活性分子,相应靶点64个,相关疾病166种。其中度值较高的候选化合物分子分别是荷包牡丹碱(37),松脂素单甲基醚(30)等;度值较高的靶点蛋白为SLC6A3,DPP4,AR,NOS2,PTGS2等;度值较高的相关疾病依次是非特异性癌症、阿尔茨海默症、乳癌、痛症、心血管病、炎症等。结论:本研究结果初步验证了金银花-连翘药对的基本药理作用及其机制,并为进一步深入揭示其作用机制奠定了良好基础。Objective： To investigate the efficacy and compatibility mechanism of Lonicerae Japonicae Flos-Weeping Forsythia herbal pairs. Method： All of chemical components related to the two traditional Chinese medicines were researched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）, in order to explore potential targets related to candidate compounds. The network pharmacological method was adopted to analyze its efficacy and compatibility mechanism. Result： According to the oral bioavailability （OB） and drug likeness （DL） conditions, 16 candidate active molecules, 64 corresponding target and 166 kinds of related diseases were screened out. The value of the first three candidate compounds were bicuculline （ 37 ） , turpentine monomethyl ether （30） , and 5-hydroxy-7-methoxy-2- 3, 4, 5-trimethoxyphenyl chromone （30）. The five target proteins with the degree value equal to 13 were SLC6A3, DPP4, AR, NOS2, PTGS2. The related diseases with high degree value were non-specific cancer, Alzheimer＇s disease, breast cancer, pain, cardiovascular disease, inflammationin the order from high to low. Conclusion： The result of the study preliminarily verifies the basic pharmacological effects of Lonicerae Japonicae Flos-Weeping Forsythia herbal pairand its related mechanisms, and lays a solid foundation for further studies on the mechanism of action.

关 键 词：网络药理学 金银花 连翘 配伍 

分 类 号：R285[医药卫生—中药学]