基于肠道菌群的中医健脾方剂作用机制的研究现状与思考  

Research Situation and Thoughts of Mechanism of Traditional Chinese Medicine Spleen Prescription Based on Intestinal Flora

作　　者：马祥雪 王凤云[2] 符竣杰 唐旭东[2] 

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院西苑医院,北京100091 [3]北京中医医院顺义医院,北京101300

出　　处：《中国实验方剂学杂志》2017年第5期210-215,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划(973计划)项目(2013CB531705);北京市科委科研基金项目(Z151100003815023)

摘　　要：肠道菌群稳态在维持肠道正常生理功能、调节机体免疫以及拮抗病原微生物定植等方面具有重要的生理意义。肠道菌群与中医理论中"脾"的生理功能密切相关,肠道菌群失调和中医脾失健运互为因果。本文从脾虚证与肠道菌群失调的联系、中医健脾方剂调节肠道菌群的研究现状2个方面进行综述,阐明从脾论治有助于恢复肠道菌群的平衡稳态,以期为进一步从微生态学角度研究中医健脾方剂作用机制提供借鉴。关于中药方剂对肠道微生态影响的研究,应密切结合临床实际,充分体现疾病或是证候的临床特点,在建立成熟的证候模型或病证结合模型的基础上,利用宏基因组学、高通量测序等微生态生物学检测方法研究中药制剂对肠道微生态结构及功能的影响,明确单味中药及其有效成分对某一疾病优势肠道细菌及其基因表达的影响,为阐明中药调节肠道微生态的有效物质基础、揭示其作用本质提供依据。Intestinal flora homeostasis in maintaining normal physiological function, regulation of body＇s immunity and antagonistic potential against pathogenic microorganisms has important physiological significance. Intestinal flora and the traditional Chinese medicine （TCM） theory of spleen is closely related in the physiological function, intestinal dysbacteriosis and TCM spleen deficiency causal each other, use the spleen prescription treated from the spleen to restore the balance of intestinal flora steady has important theoretical and practical significance. This article summarized the research status of two aspects from the connection between the spleen deficiency and the intestinal dysbacteriosis, spleen and prescription of TCM regulating intestinal flora, in order to further research from the angle of microecology of the mechanisms of spleen and prescription of TCM.

关 键 词：肠道菌群 脾虚证 四君子汤 参苓白术散 机制 健脾方剂 

分 类 号：G353.11[文化科学—情报学] R289[医药卫生—方剂学]