胆汁酸及FXR在细胞增生和分化中的作用研究进展  

Progress of the role of bile acids and FXR in cell proliferation and differentiation

作　　者：杨梅[1,2,3] 张富春[1,2] 张文宝[4,5] 

机构地区：[1]新疆大学生命科学与技术学院 [2]新疆生物资源基因工程重点实验室,乌鲁木齐830046 [3]新疆医科大学基础医学院,乌鲁木齐830011 [4]新疆医科大学第一附属医院 [5]新疆重大疾病医学重点实验室-省部共建国家重点实验室培育基地,乌鲁木齐830011

出　　处：《科技导报》2017年第4期79-83,共5页Science & Technology Review

基　　金：国家自然科学基金项目(31260272);2014新疆医科大学科研创新基金项目(XYDCX201423)

摘　　要：胆汁酸具有多种重要的生理功能,不仅与脂类物质的消化吸收密切相关,还可作为激素样信号分子在胆汁酸、脂类与糖类物质代谢及能量代谢等方面发挥重要作用。近年研究发现,胆汁酸及其核受体法尼酯X受体(FXR)在细胞增生、分化、凋亡和肝再生的调控中也发挥重要作用。本文综述了胆汁酸及其核受体FXR在细胞增生、分化、凋亡和肝再生的作用及机制,以及在寄生虫-细粒棘球绦虫成虫发育分化中作用的研究进展。The bile acids have many important physiological functions and are shown to play key roles in the digestion and absorption of dietary lipids and fat soluble vitamins as well as in regulating the bile acid homeostasis, the lipids, the glucose and the energy metabolism.Recent evidences suggest that the bile acids and their nuclear receptor FXR play an important role in the cell proliferation, the differentiation, the apoptosis and the normal liver regeneration. This review elucidates the potential role of the bile acid-FXR signaling pathway in the cell proliferation, the differentiation and the liver regeneration, as well as highlights possible mechanisms involved. With the development of the bile acid- FXR signaling pathway in the cell proliferation, the differentiation and the liver regeneration, the related fundamental scientific research will be turned into practical applications in the clinical and preventive medicine.

关 键 词：胆汁酸 法尼酯X受体 细胞增生 肝再生 细胞分化 

分 类 号：Q501[生物学—生物化学]