pH值响应性毒死蜱/铜席夫碱配合物改性SBA-15的制备及缓释性能  

Preparation and Properties of pH Value-Responsive Sustained Release System of Chlorpyrifos/Copper(Ⅱ) Schiff Base SBA-15

作　　者：林粤顺 周红军[1] 周新华[1] 龚圣[1] 徐华[1] 陈铧耀[1] LIN Yue-Shun ZHOU Hong-Jun ZHOU Xin-Hua GONG Sheng XU Hua CHEN Hua-Yao(Guangzhou Key Laboratory of Effwient Utilization of Agrochemicals, College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China)

机构地区：[1]仲恺农业工程学院化学化工学院,广州市农用化学品高效利用重点实验室,广州510225

出　　处：《无机化学学报》2017年第3期446-454,共9页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21576303,21606262);广东省自然科学基金(No.2016A030313375);广东省科技计划(No.2015A020209197);广州市科技计划(No.201510010150)资助项目

摘　　要：以3-氨丙基三乙氧基硅烷(APTES)、水杨醛和铜离子为改性剂,通过后嫁接法制得铜席夫碱配合物改性SBA-15(Cu-SBA-15),并以毒死蜱为模型药物,制备了毒死蜱/铜席夫碱配合物改性SBA-15缓释体系。利用TEM、SEM、XRD、N2吸附-脱附、TG、FTIR和XPS对SBA-15、氨基改性SBA-15(NH_2-SBA-15)、水杨醛希夫碱改性SBA-15(SA-SBA-15)的形貌、结构和Cu-SBA-15的配位情况进行了表征,考察了SBA-15在改性前后对毒死蜱的吸附量和缓释性能,并着重探究了毒死蜱/铜席夫碱配合物改性SBA-15载药体系在不同pH值下的释药行为。结果表明,APTES和水杨醛能够通过后嫁接法修饰于SBA-15,修饰后仍保持十分有序的孔道结构。SBA-15通过改性后,其对毒死蜱的吸附量由100 mg·g^(-1)增加至195 mg·g^(-1),且其对药物的缓释性能也得到改善。毒死蜱/铜席夫碱配合物改性SBA-15缓释体系显示出明显的pH值响应性,pH=3时的释药速率大于pH=11时,而在中性条件下的缓释效果相对最好。载药体系的释药行为可用Riger-Peppas动力学模型来描述,其药物释放由Fick扩散控制。Copper Schiff base modified SBA-15 （Cu-SBA-15） was prepared by post-grafting, using 3-aminopropyl triethoxysilane （APTES）, salicylaldehyde and copper ions as modifying agent. The chlorpyrifos/Cu-SBA-15 （CH- Cu-SBA-15） system were prepared by impregnation method, employing chlorpyrifos as a model drug. The morphologies and structures of SBA-15, amino functionalized SBA-15 （NH2-SBA-15）, salicylaldehyde functionalized SBA-15 （SA-SBA-15）, and Cu-SBA-15 were systematically characterized by transmission electron microscopy（TEM）, scanning electron microscopy（SEM）, X-ray diffraction assay（XRD）, N2 adsorption-desorption, TGA analysis, Fourier transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）. Meanwhile, the adsorption capacity （AC） of as-synthesized system for chlorpyrifos and sustained release performance of SBA-15 before and after modification were investigated. Besides, the sustained release behavior of CH-Cu-SBA-15 under different pH values were also discussed. The results showed that SBA-15 could be modified by APTES and salicylaldehyde, and the order structure of it was method. After modification of SBA-15, the AC of chlorpyrifos increased from sustained release performance. In addition, the CH-Cu-SBA-15 system showed still maintained by post-grafting 100 to 195 mg·g^-1 with a better significant sensitivity in response to the pH value. The chlorpyrifos release rate under pH=3 was greater than pH=11 and the sustained release performance of them was relatively better than under the neutral condition. Meanwhile, their releasing curves could be described by Riger-Peppas equation indicating that the drug release was controlled by Fick diffusion.

关 键 词：SBA-15 铜席夫碱 pH值响应 毒死蜱 缓释 

分 类 号：TQ450.6[化学工程—农药化工]