血清降钙素原和C反应蛋白对肾病综合征患者合并细菌感染的诊断价值  

Value of serum levels of procalcitonin and C-reactive protein in diagnosis of patients with nephritic syndrome complicating bacterial infection

作　　者：周佩茹[1] 吴锡信[1] Zhou Peiru Wu Xixin(Department of Nephrology, Second People＇s Hospital of Guangdong Province, Guangzhou 510000, China)

机构地区：[1]南华大学教学医院广东省第二人民医院肾内科,广州510000

出　　处：《国际医药卫生导报》2017年第5期693-695,共3页International Medicine and Health Guidance News

摘　　要：目的探讨血浆降钙素原（PCT）和C反应蛋白（CRP）对肾病综合征患者合并细菌感染的诊断价值。方法选取2015年1月至2016年7月于本院诊断为。肾病综合征患者共100例，包含50例合并细菌感染患者和50例无感染患者，选取健康者50例作为对照组。比较3组血清降钙素原和C反应蛋白水平，对两个指标的诊断价值进行比较分析。结果合并细菌感染组血清降钙素原为（3．14±0．55），C反应蛋白为（39．84±12．66），较非感染组[分别为（0．06±0．01），（3．42±1．69）]和对照组[分别为（0．05±0．01），（3．38±1．87）]均明显升高，差异均有统计学意义，非感染组较对照组差异无统计学意义（P〉0．05）。PCT灵敏度及特异度（91．0％、88．4％）均明显高于CRP（73．1％、81．4％），差异均有统计学意义（均P〈0．05）。结论血清降钙素原在肾病综合征患者合并细菌感染中的诊断价值高于C反应蛋白，二者均可用于临床监测，指导临床用药。Objective To investigate the serum levels ofprocalcitonin （ PCT ） and C-reactive protein （ CRP ） in the diagnosis of patients with nephritic syndrome complicating bacterial infection. Methods 100 patients diagnosed with nephritic syndrome at our hospital from January, 2015 to July, 2016 were selected. Among which, 50 were bacterially infected and 50 not. And 50 healthy adults were selected as a control group. The differences in the levels of PCT and CRP were compared among these three groups. The clinical values of these two indicators in the diagnose of nephritic syndrome complicating bacterial infection were analyzed. Results The levels of PCT and CRP were significantly higher in the patients with bacterial infection than in those without and the control group （ P 〈 0.05 ） . There were no statistical differences in the levels of PCT and CRP between the patients without infection and the control group （ P 〉 0.05 ） . The sensitivity and specificity of PCT were 91.0% and 88.4% and those of CRP were 73.1% and 81.4%, with statistical differences （P 〈 0.05 ） . Conclusions The serum level of PCT in the diagnosis of patients with nephritic syndrome complicating bacterial infection has higher value than the level of CRP. Both indicators are useful in clinical monitoring and therapy.

关 键 词：降钙素原 C反应蛋白 肾病综合征 细菌感染 

分 类 号：R692[医药卫生—泌尿科学]