调节性B细胞及其在移植中的研究进展  

Regulatory B Cells and Its Research Progress in Transplantation

作　　者：郝健[1] 顾钏[2] 方勇[2] 

机构地区：[1]蚌埠医学院,安徽蚌埠233030 [2]上海交通大学医学院附属第九人民医院整形外科,上海201999

出　　处：《医学综述》2017年第5期843-846,851,共5页Medical Recapitulate

基　　金：国家自然科学基金(81272081)

摘　　要：B细胞在体液免疫中起核心作用,还可促进细胞免疫。同时,B细胞还具有调节功能,不同的炎症环境刺激诱导产生不同的B细胞群体,这是一种全新的调节性B细胞(Breg),它可通过分泌白细胞介素(IL)10、IL-35及转化生长因子β等抑制性细胞因子介导发生免疫耐受,从而在移植中抑制过度炎症反应。目前对于Breg细胞的功能、表型及调节机制没有深入的认识,尤其在移植免疫中Breg细胞发挥的作用至今尚未明确。B ceils play a central role in humoral immunity and promote cellular immunity. However, recent studies fouod that B cells also have regulatory functions that different inflammatory environment stimulations induce different B cell populations. A type of new regulatory B cells （Breg） secret inhibitory cytokine interleukin （IL）-10, IL-35 and trans- forming growth factor-13 to mediate immune tolerance, resulting in inhibiting excessive intlammatory reaction in transplan- tation. But only little is known about the function and phenotype and regulation mechanism of Breg, especially in trans- plantation immunity.

关 键 词：调节性B细胞 白细胞介素10 免疫耐受 移植 

分 类 号：R622[医药卫生—整形外科]