盐酸曲美他嗪治疗冠心病稳定劳力型心绞痛的疗效观察  

Clinical efficacy of trimetazidine hydrochloride on the treatment of stable exertional angina pectoris

作　　者：孟建宏 刘亚荣[1] 王敏[1] 张林[1] Meng Jianhong Liu Yarong Wang min Zhang Lin.(The Second Affiliated Hospital of Shaanxi Universi- ty of Chinese Medicine, Xianyang 712000, China)

机构地区：[1]陕西中医药大学第二附属医院,咸阳712000

出　　处：《广西医科大学学报》2017年第3期402-405,共4页Journal of Guangxi Medical University

摘　　要：目的:观察盐酸曲美他嗪治疗冠心病稳定劳力型心绞痛的临床疗效。方法:选取2015年5—12月陕西中医药大学第二附属医院收治的冠心病稳定劳力型心绞痛患者200例,按照随机数字表法将其分为研究组和对照组,每组100例。对照组采用常规治疗方法,研究组在对照组治疗基础上加用盐酸曲美他嗪治疗。比较两组临床疗效、血脂变化及不良反应的发生率。结果:治疗后,研究组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)水平明显低于对照组,高密度脂蛋白(HDL-C)水平明显高于对照组,差异均有统计学意义(均P<0.05)。研究组心绞痛治疗总有效率为93.0%,高于对照组的82.0%,差异有统计学意义(χ~2=5.531,P<0.05)。心电图疗效评定中,研究组总有效率为84.0%,高于对照组的71.0%,差异有统计学意义(χ~2=4.845,P<0.05)。研究组不良反应发生率为5.0%,低于对照组的10.0%,两组比较差异具有统计学意义(χ~2=3.907,P<0.05)。结论:对于冠心病稳定劳力型心绞痛患者,使用传统抗心绞痛药物治疗基础上加用盐酸曲美他嗪治疗的疗效较佳,心血管不良事件发生率明显减少,且对心肌有保护作用,值得临床推广应用。Objective.To observe the clinical effect of trimetazidine hydrochloride on the treatment of stableexertional angina pectoris （SAP）. Methods. 200 patients with SAP treated in our hospital from May 2015 to December 2015 were selected and randomlydivided into a research group and a control group, with 100 cases in each group. The patients in the control group received conventional therapy, while those in the research group were treated as the control group with addition of trimetazidine hydrochloride. The clinical efficacy, blood lipid and incidence of adverse reac- tions were compared. Results： After treatment, the total cholesterol （TC）, triglyceride （TG） and low- density lipoprotein cholesterol （LDL-C） levels were lower, while the high-density lipoprotein cholesterol （HDL-C） level was higher than those in the control group （ P〈0.05）. The total response rate in treating SAP was 93.0% in the research group, which was higher than that in the control group （82. 0%） （ P〈0.05）. The effective rate in the research group was also higher than that in the control group base on the e- valuation of ECG （84.0% vs. 71.0%, P〈0.05）. The incidence of adverse reactions was 5.0% in the re- search group, and was 10.0% in the control group. There was statistical difference in the incidence of ad- verse reactions between the two groups （ P〈0.05）. Conclusion. A combination of trimetazidine hydro- chloride and conventional antianginal drugs exerted a curative effect on SAP. It could reduce the incidence of adverse cardiovascular events and protect myocardium.

关 键 词：盐酸曲美他嗪 冠心病 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]