某地区正常妊娠妇女甲状腺功能指标及正常值范围研究  

The Study on Thyroid Function and Normal Range of Normal Pregnant Women in Some Area

作　　者：吴敏[1] 马亦良[1] 陈旭日[1] WU Min MA Yi-liang CHEN Xu-ri.(Baoan District Maternal and Child Health Care Hospital of Shenzhen, Shenzhen 518000, China)

机构地区：[1]广东省深圳市宝安区妇幼保健院,广东深圳518000

出　　处：《中国医学创新》2017年第7期62-65,共4页Medical Innovation of China

基　　金：深圳市宝安区科技计划项目(2016CX249)

摘　　要：目的:研究和分析某地区正常妊娠妇女甲状腺功能指标及正常值范围。方法:选取2013年10月-2016年10月来本院妇产科进行健康常规孕检的孕妇500例作为此次报告的研究对象,按照孕妇妊娠的时间分为三组:妊早期组4~12周190例,妊中期组13~26周217例,妊晚期组27~40周93例。并选取同期来本院体检中心健康的非妊娠女性100例作为空白对照,设为对照组。分析和测量不同妊娠时间孕妇血清中游离三碘甲状腺原氨酸、游离甲状腺素、促甲状腺激素等指标的参考范围和含量水平,统计和计算美国ATA标准、国内指南标准、本次鉴定结果的阳性检出率。结果:结果显示,经过免疫发光化学测定法可知,血清FT_3中妊早期组4.38~4.93 pmol/L,妊中期组3.29~5.11 pmol/L,妊晚期组2.97~5.02 pmol/L。血清FT_4中:妊早期组10.64~12.03 pmol/L,妊中期组8.52~17.12 pmol/L,妊晚期组6.38~15.84 pmol/L。血清TSH中:妊早期组1.09~1.99 mU/L,妊中期组1.42~3.1 mU/L,妊晚期组1.73~3.45 mU/L。四组孕妇的血清含量测定可知,妊娠期孕妇的FT_3、FT_4、TSH水平均低于对照组,比较差异均有统计学意义(P<0.05)。按照美国ATA和国内指南标准,本研究指出妊娠孕妇中甲状腺功能减退率4.0%,亚临床甲减率3.6%,低T4血症率1.8%,TPOAb阳性率6.4%。结论:明确某地区正常妊娠妇女甲状腺功能指标及正常值范围有利于妊娠期甲状腺功能异常疾病的早期诊断和治疗。Objective： To study and analyze the thyroid function and normal range of normal pregnant women in some area.Method： From October 2013 to October 2016, 500 pregnant women with gynecological obstetrics and gynecology in our hospital were selected as the study objects.According to the time of pregnancy, the pregnant women were divided into three groups： early pregnancy group （ 12 weeks ） of 190 cases, the second trimester of pregnancy group （ 13 to 26 weeks ） of 217 cases, late pregnancy group （ 27 to 40 weeks ） of 93 cases.And 100 healthy non-pregnant women were selected as the control group.The levels of free triiodothyronine, free thyroxine and thyroid stimulating hormone in serum of pregnant women at different gestation time were analyzed and measured.The results were statistically and statistically analyzed by ATA standard, national guideline standard, The detection rate.Result： The result of immuno-chemiluminescence assay showed that serum FT3 in early pregnancy group was 4.38-4.93 pmol/L, in the second trimester of gestation group was 3.29-5.11 pmo]/L, late pregnancy was 2.97-5.02 pmol/L.Serum FT4 in the early pregnancy group was 10.64-12.03 pmol/L, the second trimester of gestation group was 8.52-17.12 pmol/L, late pregnancy group was 6.38-15.84 pmol/L.Serum TSH in early pregnancy group was 1.09-1.99 mU/L, the second trimester of gestation group was 1.42-3.1 mUlL, late pregnancy group was 1.73-3.45 mUlL.The serum FT3, FT4 and TSH levels in pregnant women were lower than those in the control group, there were significant differences （P〈0.05） .In accordance with the United States ATA and domestic guidelines, this study indicates that pregnant women the rate of hypothyroidism was 4.0%, subclinical＇hypothyroidism was 3.6%, low T4 hypeilipidemia was 1.8%, the positive rate of TPOAb was 6.4%.Conclusion： It is clear that the thyroid function index and the normal range of normal pregnant women in some area are helpful for the early diagnosis and treatment of abnormal thyroid function in

关 键 词：正常妊娠 甲状腺功能 应用价值 

分 类 号：R714[医药卫生—妇产科学]