血必净注射液对改善严重多发伤患者预后作用的研究  

Study on the Improvement of Xubijing Injection on Prognosis of Patients with Severe Multiple Trauma

作　　者：连向阳[1] 古纪欢[1] 王金宝[1] 罗友林[1] 叶梦思[1] LIAN Xiang-yang GU Ji-huan WANG Jin-bao et al(Shenzhen Shajing Hospital, Affiliated to Guangzhou Medical University, Shenzhen 518104, China)

机构地区：[1]广州医科大学附属深圳沙井医院,广东深圳518104

出　　处：《中国医学创新》2017年第7期77-81,共5页Medical Innovation of China

摘　　要：目的:观察血必净注射液对严重多发伤患者炎症因子、凝血功能及肝肾功能的影响,探讨其对严重多发伤患者预后的改善作用。方法:将本院2012年1月-2014年1月收治的76例严重多发伤患者按随机数字表法分为治疗组和对照组,每组38例。对照组予以常规综合治疗,治疗组在对照组的基础上早期加用0.9%氯化钠注射液100 mL+血必净注射液100 mL,静脉滴注,2次/d,连续用药7 d。分别检测两组在治疗前和治疗后7 d的炎症因子水平、凝血功能指标以及反应肝肾功能的检验指标,并观察两组患者并发症发生率、死亡率,同时记录急性生理和慢性健康状况(APACHEⅡ)评分。结果:与治疗前相比,治疗第7天观察组并发症发生率、APACHEⅡ评分以及炎症因子水平均有所下降,凝血功能、肝肾功能均明显改善,比较差异均有统计学意义(P<0.05),两组间比较差异均有统计学意义(P<0.05),提示治疗组指标下降幅度(改善幅度)大于对照组。结论:早期应用血必净注射液可以从一定程度上改善严重多发伤患者的预后,其机制可能与血必净注射液能够减少炎性介质的释放、改善凝血功能从而对人体重要脏器具有保护作用有关。Objective： To observe the influences of Xuebijing Injection on inflammatory factors, blood coagulation function and liver and kidney function of patients with severe multiple trauma, to explore its improvement on patients with severe multiple trauma.Method： 76 patients with severe multiple trauma were selected in our hospital from January 2012 to January 2014, they were divided into the treatment group and the control group according to the random number table method, 38 cases in each group.The control group was given routine comprehensive treatment, while the treatment group was added with 100 mL of 0.9% NS＋100 mL of Xuebijing Injection, intravenous drip, twice daily for consecutive 7 days on the basis of routine comprehensive treatment.Before and after treatment, the inflammatory factors, blood coagulation indicators, liver and kidney function of two groups were detected, the incidence of complications and mortality of two groups were observed, the acute physiology and chronic health conditions （ APACHE ]] scores ） of two groups were recorded.Result： Compared with before treatment, the incidence of complications, APACHE ]I scores and inflammatory factor levels of two groups after treatment were decreased on the 7th day, the blood coagulation function, liver and kidney function of two groups after treatment were obviously improved, the differences were statistically significant （ P〈0.05 ） . And the decline （ improvement ） of the indexes in the treatment group were better than those of the control group, the differences were statistically significant （P〈0.05） .Conclusion： Early application of Xuebijing Injection can improve the prognosis of patients with severe multiple trauma to certain extent, and its mechanism may be related to that Xuebijing Injection can reduce the release of inflammatory mediators and improve the function of blood coagulation so as to protective important organs of human body.

关 键 词：血必净注射液 严重多发伤 炎症反应 凝血功能 预后 

分 类 号：R641[医药卫生—外科学]