沿不同缝合方向皮肤应力的有限元分析  

Finite element analysis of skin closure stress in different directions

作　　者：吕营[1] 安美文[1] 侯春胜 Lv Ying An Mei-wen Hou Chun-sheng(Taiyuan University of Technology, Institute of Applied Mechanics and Biomedical Engineering, Taiyuan 030024, Shanxi Province, China General Hospital of TISCO, Burn Center of Shanxi Province, Taiyuan 030009, Shanxi Province, China)

机构地区：[1]太原理工大学,应用力学与生物医学工程研究所,山西省太原市030024 [2]太钢总医院,山西省烧伤救治中心,山西省太原市030009

出　　处：《中国组织工程研究》2017年第4期609-614,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(11372208);山西省自然科学基金(2013011002-4)~~

摘　　要：背景:力学因素在皮肤伤口愈合和瘢痕形成的过程中有重要作用。目前利用有限元方法模拟、分析及优化各种缝合方式并精确指导外科手术,成为一个重要课题。目的:通过建立皮肤有限元模型,分析单纯间断缝合不同缝合方向的皮肤伤口应力分布,为研究瘢痕的形成提供基础数据。方法:通过猪背皮肤单轴拉伸试验,为人体皮肤力学性能提供参考;利用ABAQUS建立正交各向异性的皮肤伤口模型,并计算沿不同缝合方向皮肤伤口的应力分布。结果与结论:(1)皮肤的各向异性对皮肤伤口缝合应力影响明显,沿朗格氏线(Langer's lines)方向的弹性模量大于其垂直方向的弹性模量;(2)伤口缝合应力按照朗格氏线方向伤口、朗格氏线方向偏转30°伤口、朗格氏线方向偏转45°伤口、垂直朗格氏线方向伤口的顺序依次增大;(3)结果提示,临床手术切口宜沿着朗格氏线方向,除此之外,切口偏转朗格氏线一定的角度也可以减小缝合应力。BACKGROUND： Mechanical factors play an important role in wound healing and scar formation. Finite element model is established to stimulate, analyze and optimize different sutures, which has become a hotspot to guidesurgies accurately. OBJECTIVE： To analyze the stress distribution of different simple interrupted suturing directions on the skin wound by establishing the skin finite element model, and to provide basic data for the study of scar formation. METHODS： Porcine back skin uniaxial tensile test was performed to provide reference for the mechanical properties of human skin. Orthotropic skin wound model was established using ABAQUS to calculate the stress distribution on the wound in different suturing directions. RESULTS AND CONCLUSION： The anisotropic mechanical properties of skin wound influenced the suture stress significantly. The elastic modulus along the Langer＇s line was larger than that in the vertical direction. The stress increased orderly in the Langer＇s line direction, the Langer＇s line deflected 30°, bias Langer＇s line 45° and vertical Langer＇s line. These results suggest that the clinical incision should be made along the Langer＇s line direction. Additionally, the cut at an angle with Langer＇s line can also reduce the stress of suture.

关 键 词：瘢痕 瘢痕疙瘩 应力 物理 有限元分析 组织工程 组织构建 伤口 缝合 各向异性 朗格氏线 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]