卵巢癌患者红细胞分布宽度的变化及临床意义  

Change of red cell distribution width(RDW)in patients with ovarian cancer and its clinical significance

作　　者：唐闻[1] 鞠瑛[1] 沈亚娟[1] 张倡誌 成士清[1] 王勇[1] 张炳昌[1] 

机构地区：[1]山东大学附属省立医院临床医学检验部,济南250021

出　　处：《检验医学与临床》2017年第5期601-603,共3页Laboratory Medicine and Clinic

基　　金：国家自然科学基金资助项目(81000731);山东省优秀中青年科学家奖励基金资助项目(B2010YY045)

摘　　要：目的探讨卵巢癌患者红细胞分布宽度(RDW)的变化及临床应用。方法选择卵巢癌患者182例,术前抽血检测血常规、肿瘤标志物等相关指标,并选取782例体检健康志愿者(健康对照组)和200例卵巢囊肿患者(卵巢囊肿对照组)进行比较。比较3组中RDW水平,并绘制受试者工作特征(ROC)曲线,根据卵巢癌患者RDW水平分为高RDW组(RDW≥13.75%)和低RDW组(RDW<13.75%),分析RDW与卵巢癌肿瘤指标[癌胚抗原(CEA)、糖类抗原(CA)199、CA153、CA125和CA724]的关系。结果卵巢癌患者RDW水平高于健康对照组,差异有统计学意义(Z=-2.037,P<0.05);卵巢癌患者RDW水平与卵巢囊肿患者比较,差异无统计学意义(Z=-0.659,P>0.05)。高RDW组和低RDW组患者的CA125水平差异有统计学意义(P<0.05),而与其他肿瘤标志物比较,差异无统计学意义(P>0.05)。结论 RDW在卵巢癌和卵巢囊肿中升高,并与卵巢癌患者的肿瘤指标CA125有关。Objective To study the change of red cell distribution width（RDW）in the patients with ovarian cancer and its clinical application.Methods A total of 182 patients with ovarian cancer were selected and detected the related indicators of blood routine and tumor markers before operation.Meanwhile 782 persons undergoing the physical examination（healthy control group）and200cases of ovarian cyst were selected for conducting the comparison.The RDW levels were compared among these three groups.The patients with ovarian cancer（ovarian cyst control group）were divided into high RDW group（RDW≥13.75%）and low RDW group（RDW13.75%）based on the receiver operating characteristic（ROC）curve and RDW levels.Then the relationship between RDW level and ovarian cancer associated with tumor markers[such as carcinoembryonic antigen（CEA）,carbohydrate antigen 199（CA199）,carbohydrate antigen 153（CA153）,carbohydrate antigen 125（CA125）and carbohydrate antigen 724（CA724）].Results The RDW level in the ovarian cancer group was significantly higher than that in the healthy control group with statistical difference（Z=-2.037,P〈0.05）.But there was no statistical difference in RDW level between the patients with ovarian cancer and the patients with ovarian cyst（Z=-0.659,P〉0.05）.Furthermore,the CA125 level had statistical difference between the high RDW group and low RDW group（P〈0.05）,but other tumor markers had no statistical difference（P〉0.05）.Conclusion The RDW level is increased in ovarian cancer and ovarian cyst.And the RDW level in the patients with ovarian cancer is related with tumor marker CA125.

关 键 词：卵巢癌 红细胞容积分布宽度 糖类抗原125 

分 类 号：R556[医药卫生—血液循环系统疾病]