脂肪干细胞旁分泌功能在面部抗衰老领域的研究应用与进展  

Research progress and application outlook of paracrine functions of adipose-derived stem cells in facial anti-aging

作　　者：郭吉安[1] 余丕军[1] 王露萍[1] 石莹莹[1] 柳逸[1] 陈炜[1] Guo Ji-an Yu Pi-jun Wang Lu-ping Shi Ying-ying Liu Yi Chen Wei(Department of Plastic Surgery, Shanghai Eighth People＇s Hospital of Jiangsu University, Shanghai 200235, Chin)

机构地区：[1]江苏大学附属上海市第八人民医院医学美容科,上海市200235

出　　处：《中国组织工程研究》2017年第5期789-794,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:脂肪干细胞是从脂肪组织中获得的间充质干细胞,具有旁分泌功能,已成为当前研究的热点。目的:就脂肪干细胞旁分泌功能的基础研究及其在抗面部衰老方面的应用进展做一综述。方法:分别以"adipose-derived stem cells,paracrine,anti-aging"和"脂肪干细胞,旁分泌,抗衰老"为检索词,由第一作者检索2001年1月至2016年5月Pub Med数据库和中国期刊全文数据库相关文章。排除重复性及缺乏原创性的文献,计算机初检得到176篇文献,最终保留66篇进行归纳总结。结果与结论:脂肪干细胞具有旁分泌功能,可分泌多种生长因子(如表皮生长因子、转化生长因子β、血小板衍生生长因子、血管内皮生长因子、胶原蛋白和纤维粘连蛋白等)及炎性因子(干扰素γ、白细胞介素1β、白细胞介素8、白细胞介素9及肿瘤坏死因子α等),在抑制皮肤老化、美白肌肤、辅助脂肪移植、促进毛发再生等诸多抗衰老方面均有较显著的效果。BACKGROUND： Adipose-derived stem cells（ADSCs） are a subset of mesenchymal stem cells obtained from adipose tissue, which have paracrine functions, already becoming a focus in anti-aging researching. OBJECTIVE： To review the research progress and application outlook of ADSCs＇ paracrine functions in facial anti-aging.METHODS： The first author searched the Pub Med and CNKI databases using the keywords of ＂adipose-derived stem cells, paracrine, anti-aging＂ in English and Chinese, respectively, to retrieve relevant articles published from January 2001 to May 2016. Repetitive articles or those with no originality were eliminated. Totally 176 articles were searched initially, and 66 articles were included in result analysis. RESULTS AND CONCLUSION： ADSCs have paracrine function, which can secrete various growth factors（e.g., epidermal growth factor, transforming growth factor β, platelet-derived growth factor, vascular endothelial growth factor, collagen and fibronectin） and inflammatory factors（e.g., interferon-γ, interleukin-lβ, interleukin-8, interleukin-9, interleukin-12, interleukin-15, interleukin-17 and tumor necrosis factor-α）. These paracrine products of ADSCs have significant effects on anti-aging, such as inhibiting skin aging, whitening skin, assisting lipotransfer, promoting hair regeneration.

关 键 词：干细胞 衰老 组织工程 脂肪干细胞 旁分泌 细胞因子 抗衰老 皮肤老化 美白 脂肪移植 脱发 

分 类 号：R318[医药卫生—生物医学工程]