脂肪干细胞生物学特性及在口腔再生医学中的应用  

The biological features of adipose-derived stem cells and its application in oral tissue regeneration

作　　者：罗远[1] 黄远亮[2] Luo Yuan Huang Yuan-liang(Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China Department of Stomatology, Dongfang Hospital of Tongji University, Shanghai 200120, China)

机构地区：[1]同济大学口腔医学院口腔颌面外科教研室上海牙组织修复与再建工程技术研究中心,上海市200072 [2]同济大学附属东方医院口腔科,上海市200120

出　　处：《中国组织工程研究》2017年第5期795-801,共7页Chinese Journal of Tissue Engineering Research

基　　金：上海市科技委员会基金(14411963500);名称:新型淫羊藿苷缓释支架材料修复种植体周围骨缺损的实验研究;上海市卫计委青年项目(20154Y0200);名称:富血小板纤维蛋白(PRF)在下颌第三磨牙拔除后第二磨牙远中牙槽嵴保存的应用~~

摘　　要：背景:相比较于其他组织来源的干细胞,脂肪干细胞不仅来源广泛,获取方便,而且有强大的扩增和分化潜能,这些特点使其在口腔再生医学中有着广阔的应用前景。目的:总结脂肪干细胞的生物学特点及其在口腔再生医学中的研究进展。方法:以"脂肪干细胞,口腔组织再生,骨组织工程;牙周再生;骨缺损;adipose-derived stem cells,oral tissue regeneration,bone tissue engineering,periodontal tissue regeneration,bone defects"为检索词,应用计算机检索Pub Med、CNKI、万方数据库2000至2016年的相关文献。结果与结论:在体外牙周组织再生研究中,脂肪干细胞可以促进骨组织再生、成纤维组织再生、血管组织再生及提高牙周创面愈合能力。在口腔颅颌面骨再生研究中,脂肪干细胞作为种子细胞,可成功修复种植术前的牙槽骨缺损及外伤和肿瘤术后的大面积骨缺失。脂肪干细胞移植后的免疫原性和安全性等问题还需要进一步研究。BACKGROUND： In comparison with stem cells from other tissues, adipose-derived stem cells（ADSCs） are not only abundant and easy to harvest but also have the strong abilities to proliferate and differentiate. These make ADSCS the promising stem cells in the field of oral tissue regeneration. OBJECTIVE： To summarize the biological features of ADSCs and the development of functions as stem cells in the oral tissue regeneration. METHODS： We took ＂adipose-derived stem cells, oral tissue regeneration, bone tissue engineering, periodontal tissue regeneration, bone defects＂ as the key words in Chinese and English, respectively, to retrieve the related literatures from Pub Med, CNKI, Wangfang databases during 2000 to 2016 based on internet search. RESULTS AND CONCLUSION： In vitro studies on periodontal tissue regeneration have shown that ADSCs can promote the regeneration of bones, fibroblasts, blood vessels around the periodontal area, and improve the healing abilities of injured tissues. In the study of craniofacial bone regeneration, ADSCs can successfully repair massive bone loss due to the surgeries of tumor or accidents. ADSCs have a promising role in the oral tissue regeneration, but further studies will be required because of the problems of immunogenicity and safety.

关 键 词：干细胞 脂肪组织 引导组织再生 牙周 组织工程 脂肪干细胞 口腔组织再生 骨组织工程 牙周再生 骨缺损 

分 类 号：R318[医药卫生—生物医学工程]