血小板微小RNA与心血管疾病研究进展  

Progress of platelet microRNAs in cardiovascular disease

作　　者：杨文龙[1] 张俊峰[1] YANG Wen-long ZHANG Jun-feng(Department of Cardiology, Shanghai Ninth People＇s Hospital, Medical School, Shanghai Jiaotong University, Shanghai 201999, China)

机构地区：[1]上海交通大学医学院附属第九人民医院心内科,上海201999

出　　处：《心脏杂志》2017年第2期228-231,共4页Chinese Heart Journal

基　　金：上海申康适宜技术推广项目资助(SHDC12012210);上海市宝山区科委项目资助(12-E-63)

摘　　要：心血管疾病(cardiovascular disease,CVD)是当今社会危害人类健康和生命最主要的疾病之一,血小板的病理性激活在CVD的发病过程中起着重要作用。微小RNA(miRNA)是一类在转录后水平调控基因表达的小分子RNA,参与多种疾病的发生发展,多种miRNA都与CVD密切相关,研究表明血小板含有丰富的miRNA,本文就血小板来源的miRNA在CVD中的作用进行综述。Cardiovascular disease is the most hazardous to human health. Pathologically activated platelets play an important role in the pathogenesis of cardiovascular diseases, mieroRNAs are a class of small RNAs playing a role in post-transcriptional regulation of gene expressions and are involved in the develop- ment of many diseases. Many microRNAs are closely associated with cardiovascular disease. Studies have shown that platelets are rich in microRNAs and the role of platelet-derived microRNAs in cardiovascular disease is reviewed in this paper.

关 键 词：心血管疾病 血小板 微小RNA 

分 类 号：R54[医药卫生—心血管疾病]