中药预防性保肝对乳腺癌化疗所致药物性肝损伤的临床观察  

Clinical observation of preventive hepatoprotective effect of traditional Chinese medicine on drug -induced liver injury induced by chemotherapy of breast cancer

作　　者：李丹[1] 蓝兰[1] 陈盼[1] 李卓虹[1] 安佰平[2] 祝朝富 Li Dan Lan Lan Chen Pan Li Zhuohong An Baiping Zhu Chaofu(Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China Department of Oncology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China)

机构地区：[1]成都中医药大学,四川省成都610075 [2]成都中医药大学附属医院肿瘤科,四川省成都610072

出　　处：《中国基层医药》2017年第5期698-701,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察使用及未使用保肝中药化疗患者的肝损伤发生率，探讨中药预防性保肝治疗的有效性及意义。方法采用回顾性分析，比较观察组（中药保肝）及对照组（未予中药及西药保肝）化疗后丙氨酸氨基转氨酶（ALT）、天冬氨酸氨基转氨酶（AST）、总胆红素（TBIL）、碱性磷酸酶（ALP）等肝功能指标变化及药物性肝损伤发生情况。结果观察组肝损伤发生率4．7％（2／43），对照组肝损伤发生率23．9％（11／46）。两组间差异有统计学意义（χ^2＝6．611，P ＝0．01）。治疗后 ALT、AST、TBIL、ALP 等肝功能指标，两组差异有统计学意义（P 〈0．05）。结论中药预防性保肝治疗能改善肝功能指标异常，降低化疗所致药物性肝损伤的发生率。Objective To assess the efficacy and significance of hepatic protection by observing the incidence of liver injury in patients with chemotherapy who were treated and untreated with traditional Chinese medicine （TCM）.Methods A retrospective analysis was applied to compare the changes in liver function tests and incidence rate of drug -induced liver injury between the observation group （treated with TCM）and the control group （untreated with TCM）after chemotherapy.Results The incidence rates of liver injury in the observation group and control group was 4.7%（2 /43）and 23.9%（11 /46）respectively.The difference between the two groups was statisti-cally significant（χ^2 =6.611,P =0.01）.The ALT,AST,TBIL,ALP between the two groups had statistically signifi-cant differences after treatment （all P 〈0.05）.Conclusion Using TCMin hepatic protection can improve liver tests and reduce the incidence of drug -induced liver injury from chemotherapy.

关 键 词：药物性肝损伤 乳腺肿瘤 医学 中国传统 

分 类 号：R273[医药卫生—中西医结合]