更昔洛韦治疗人类疱疹病毒4型感染患儿的效果  

Effect of ganciclovir in treatment of children with human herpesvirus 4 infection

作　　者：张佳佳[1] 胡赤军[1] ZHANG Jia-Jia HU Chi-Jun.(Department of Pediatrics, Hubei Provincial Maternal and Child Health Care Hospital, Wuhan, Hubei 430070, Chin)

机构地区：[1]湖北省妇幼保健院儿内科,湖北武汉430070

出　　处：《中国妇幼保健》2017年第5期991-994,共4页Maternal and Child Health Care of China

摘　　要：目的探讨更昔洛韦治疗儿童EB病毒感染的效果,寻找适合临床的最佳治疗方案。方法搜集EB病毒感染患儿共90例,随机分为两组,对照组采用一般对症治疗,酌情使用抗生素。而治疗组在上述常规治疗基础上,加用更昔洛韦抗EB病毒治疗,用量5 mg/kg,每12 h一次静脉点滴,静滴时间不少于1 h,疗程10~14 d。比较两组热程、咽峡及扁桃体恢复时间、淋巴结缩小时间、肝功能恢复时间、平均住院天数。并根据上述结果按有效、显效和无效进行比较。结果治疗组热程(7.64±2.34)d、淋巴结明显缩小所需时间(5.38±1.85)d、平均住院日(9.44±2.31)d,对照组热程(10.36±2.21)d、淋巴结明显缩小所需时间(8.95±2.14)d、平均住院日(12.07±2.36)d,治疗组各项指标均短于对照组(P<0.05);治疗后两组患儿肝脏、脾脏缩至正常及肝酶改善情况有统计学差异(P<0.05);治疗组显效率(60.00%)明显高于对照组(44.40%),两组比较,差异有统计学意义(P<0.05)。结论更昔洛韦治疗儿童EB病毒感染安全有效,是值得推广的治疗EB病毒感染的有效药物。Objective To explore the effect of gancielovir in treatment of children with human herpesvirus 4 （HHV-4） infection, find the best treatment option suitable for clinical application. Methods Ninety children with HHV-4 infection were collected and randomly divided into two groups. The children in control group were treated by general symptomatic treatment and appropriate use of antibiotics, and the children in treatment group were treated by ganciclovir （5 mg/kg, intravenous drip more than one hour） based on conventional therapy, the course of treatment was 10-14 days. The duration time of fever, the recovery time of isthmus faucium and tonsil, the time of lymph nodes decrease, the recovery time of liver function, the average hospitalization time in the two groups were compared; the curative effects in the two groups were compared according to effective, excellently effective and infective based on the above-mentioned results. Results In treatment group, the duration time of fever was （7.64±2. 34） days, the time of lymph nodes decrease needed （5.38± 1.85 ） days, the average hospitalization time was （9.44±2. 31 ） days; in control group, the duration time of fever was （ 10. 36±2. 21 ） days, the time of lymph nodes decrease needed （8. 95 ±2. 14） days, the average hospitalization time was （ 12. 07 ±2. 36） days. The duration time of fever, the time of lymph nodes decrease, and the average hospitalization time in treatment group were statistically significantly shorter than those in control group （P〈 0.05 ） . After treatment, there were statistically significant differences in the time of liver and spleen return to normal and improvement of liver enzyme between the two groups （ P〈0. 05） . The excellently effective rate in treatment group （60. 00% ） was statistically significantly higher than that in control group （44.40%） （P〈0.05） . Conclusion Ganciclovir is safe and effective in treatment of children with HHV- 4 infection, which is worthy of clinical promot

关 键 词：更昔洛韦 EB病毒感染 儿童 

分 类 号：R725.9[医药卫生—儿科]