肺炎支原体肺炎血清白介素-10、肿瘤坏死因子-α、D2-聚体的表达及意义  

Expression and significance of IL-10,TNF-α,and D-dimer in the serum among patients with mycoplasma pneumonia

作　　者：姚蔚峦[1] YAO Wei-luan(Taiyuan City Maternal and Child Care Hospital, Taiyuan, Shanxi, 030012, China)

机构地区：[1]太原市妇幼保健院,山西太原030012

出　　处：《预防医学论坛》2017年第1期49-51,54,共4页Preventive Medicine Tribune

摘　　要：目的分析支原体肺炎患儿血清白介素-10、肿瘤坏死因子-α、D2-聚体表达情况。方法选择2015年1月至2016年6月于我院儿科住院重症肺炎支原体肺炎患儿51例作为观察组,另选取轻症支原体肺炎60例作为对照组,检测急性期及恢复期观组和对照组患儿白介素-10、肿瘤坏死因子-α、D2-聚体水平变化。结果观察组肿瘤坏死因子-α水平急性期、恢复期SMPP患儿血清与对照组比较均明显升高(P<0.05);在观察组中,急性期明显高于恢复期(P<0.05)。观察组D2-聚体水平在急性期明显高于对照组(P<0.05);而在恢复期与对照组无显著差异(P>0.05);观察组中,急性期和恢复期间也无显著差异(P>0.05)。观察组白介素-10水平在急性期和恢复期与对照组均无显著差异(P>0.05);观察组中,急性期和恢复期间也无显著差异(P>0.05)。结论肿瘤坏死因子-α可以作为重症支原体肺炎的预测指标和疾病恢复情况的评价指标之一。白介素-10在疾病不同时期的变化尚待进一步研究。D2-聚体对识别重症MPP及高凝状态有一定意义。Objective To analyze the expression of IL-10,TNF-αand D-dimer in the serum among patients with mycoplasma pneumonia. Methods A total of 51 children with servere mycoplasma pneumonia pneumonia （SMPP） who were admitted in the hospital were included in study and served as the observation group during January 2015-June 2016 ,and 60 mild mycoplasma pneumonia pneumonia at the same time were chosen as the control group. The level of IL-10,TNF-α,D- dimer in the observation group at the acute phase and recovery phase were detected and compare with the control group. Results When compared with the control group,the serum TNF-α levels in the observation group at the acute phase and recovery phase were significantly elevated（ P 〈0.05）. The serum TNF-α levels in SMPP patients at the acute phase were significantly elevated than those at the recovery phase（ P 〈0.05）. The serum D-dimer levels at the acute phase in SMPP patients were significantly elevated than those in mild patients（ P 〈0.05） ;At the recovery phase, the comparison of I^di- mer was not statistically significant（ P 〉0.05） ;The serum D-dimer levels in SMPP patients at the acute phase were not statistically significant（ P 〉0.05）. IL-10 levels in SMPP and mild patients in the acute phase were not significantly different from those in recovery phase（ P 〉0.05）. Conclusion TNFα can be used as a predictor of severe myeoplasma pneumoniae pneumonia and evaluation indexes of disease recovery. IL-10 changes in different periods of disease remain to be future studied. D2-dimer has a certain significance in identifying severe MPP and high condensation state.

关 键 词：白介素-10 肿瘤坏死因子-Α D2-/聚体 儿童 肺炎支原体肺炎 

分 类 号：R375.2[医药卫生—病原生物学]