组蛋白甲基化修饰与哺乳动物生殖  

Histone methylation modification and mammalian reproduction

作　　者：廖晖淇 张昌军[1] 刁红录[1] Liao Huiqi Zhang Changjun Diao Honglu.(Reproductive Medicine Center, Renmin Hospital, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, Chin)

机构地区：[1]湖北医药学院附属人民医院生殖医学中心胚胎干细胞湖北省重点实验室生物医学工程学院,十堰442000

出　　处：《生殖与避孕》2017年第1期81-85,共5页Reproduction and Contraception

基　　金：湖北省自然科学基金(2015CFB543);湖北医药学院中青年创新团队(2014CXX03);湖北医药学院重点学科建设资助项目~~

摘　　要：组蛋白甲基化是表观遗传学研究的热点和难点,研究表明,组蛋白甲基化修饰在哺乳动物配子的发生、胚胎着床和发育以及胎盘的发育过程中有着特殊作用,这些修饰可影响基因的表达,从而动态调节哺乳动物生殖过程中许多生物学进程。但目前研究的组蛋白甲基化修饰相关基因位点多而杂,且多停留在广泛的探索和描述这一层面,这些甲基化修饰发生动态变化的机制,以及相互作用等一系列过程还有待深入研究。Histone methylation has been the focus and difficulty of epigenetic research. Previous studies have shown that histone methylation modification plays an important role in mammalian gametogenesis, embryo implantation and development, and placenta development. These modifications may affect gene expression to dynamically regulate mammalian reproduction in many biological processes. But the study of histone methylation related many and complex gene loci, and stays in a wide range of exploration and description. The mechanism of these methylation changes dynamically, and the interaction of a series of processes to be further studied.

关 键 词：组蛋白甲基化 组蛋白去甲基化 生殖 哺乳动物 配子发生 胚胎发育 

分 类 号：R339.2[医药卫生—人体生理学]