他克莫司血药浓度与胱抑素C在肾移植受者中的相关性分析  

Correlation of Tacrolimus Blood Concentration and Cystatin C in the Patients with Renal Transplantation

作　　者：蒋艳[1] 邹素兰[1] 陈荣[1] 吴萍[1] 许贤林[2] 姜庆波[3] Jiang Yan Zou SulanI Chen RongI Wu Ping Xu Xianlin Jiang Qingbo(Department of Pharmacy Department of Urinary Surgery Department of Clinical Laboratory, Changzhou Municipal First People＇ s Hospital, the Third Affiliated Hospital of Suzhou University, Jiangsu Changzhou 213003, China)

机构地区：[1]苏州大学附属第三医院常州市第一人民医院药剂科,江苏常州213003 [2]苏州大学附属第三医院常州市第一人民医院泌尿外科,江苏常州213003 [3]苏州大学附属第三医院常州市第一人民医院检验科,江苏常州213003

出　　处：《中国药师》2017年第3期488-490,共3页China Pharmacist

基　　金：常州市第三十五批科技计划项目(编号:CY20119021)

摘　　要：目的:回顾性分析肾移植受者术后他克莫司(Tac)的血药浓度与肾功能指标血清胱抑素C(SCysC)以及血清肌酐(SCr)的相关性。方法:纳入84例服用Tac的肾移植受者,其中男67例,女17例,收集其Tac血药浓度、SCysC和SCr数据;分别按术后时间、血药浓度分组,将浓度与SCysC、SCr进行Pearson相关分析,比较不同时间段及浓度水平下血药浓度分别与SCysC、SCr的相关性。结果:术后不同时间段内,Tac血药浓度与SCysC、Scr没有显著相关性(P>0.05);不同药物浓度水平组,血药浓度与SCysC、Scr亦没有显著相关性。随着术后时间的延长,Tac血药浓度呈逐渐下降的趋势,SCysC、Scr水平先是降低,术后两年又逐渐上升。结论:Tac血药浓度不影响SCysC和Scr等生化指标对于移植肾功能的评价。Objective： To investigate the correlation of the blood concentration of tacrolimus （Tac） and serum cystatin C （SCysC） and serum creatinine （Scr） in the patients with renal transplantation. Methods： Totally 84 cases of renal transplantation patients （67 male/17 female） treated with Tac were involved. The blood concentration of Tac, SCysC and Scr were monitored after the operation. Data results were categorized according to the postoperative time and the blood concentration. The correlations of Tac blood concentra- tion, SCysC and Scr were analyzed and compared by using Pearson correlation analysis. Results： The blood concentration of Tac was not significantly associated with SCysC and Scr in different postoperative time groups and different drug concentration groups （ P 〉 0.05）. As the extension of time, the blood concentration of Tac showed a gradual declining trend, while SCysC and Scr levels de- creased first, and then increased gradually after two years of the operation. Conclusion： The blood concentration of Tac has no effect on the function evaluation of transplanted kidney by the biochemical indicators such as SCysC and Scr.

关 键 词：肾移植 他克莫司 血药浓度 血清胱抑素C 血清肌酐 

分 类 号：R969.1[医药卫生—药理学]