Influence of acupoint-injection on TXB_2 and 6-keto-PGF_(1a) in patients with pseudobulbar palsy: a randomized controlled trial  

穴位注射对假性延髓麻痹患者TXB_2和6-keto-PGF_(1a)的影响的随机对照试验（英文）

作　　者：Liu Ji-ye Chen Ying-hua 刘继业;陈英华(College of Clinical Medicine, Heilongjiang University of Chinese Medicine;Department of Acupuncture and Moxibustion, the First Hospital Affiliated to Heilongjiang University of Chinese Medicine)

机构地区：[1]College of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China [2]Department of Acupuncture and Moxibustion, the First Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin 150040, China

出　　处：《Journal of Acupuncture and Tuina Science》2017年第1期22-26,共5页针灸推拿医学（英文版）

基　　金：supported by Chinese Medicine Scientific Research Program of Heilongjiang,No.ZH04B06~~

摘　　要：Objective： To prove the feasibility and validity of Xing Nao Jing acupoint-injection （XNJ-AI） at Fengchi （GB 20） for pseudobulbar palsy caused by ischemic stroke （PBP-IS）. Methods： An assessor-blinded, two-parallel-group, randomized controlled trial was conducted, and the patients with PBP-IS were recruited and randomly divided into two groups. Patients in the control group received oral aspirin （100 mg per day for 2 weeks）. In addition to oral aspirin; patients in the treatment group received XNJ-AI at Fengchi （GB 20）, once a day, for two weeks. The primary outcome was assessed by the water-swallowing test （WST）. Thromboxane B2 （TXB2） and 6-keto-prostaglandin F1α （6-keto-PGF1α） in plasma were measured before and after the treatment. Results： In the treatment group, the percentage of swallowing function no less than grade 3 before and after the treatment was 32% and 88%, respectively; in the control group, it was 28% and 76% before and after the treatment, respectively; the difference after the treatment between the two groups was statistically significant （P〈0.05）. There were statistical differences between pre- and post-treatment levels of plasma TXB2 and 6-keto-PGF1α in the two groups （both P〈0.05）. After the treatment, there were significant differences in the levels of plasma TXB2 and 6-keto-PGF1α between the two groups （both P〈0.05）. Conclusion： XNJ-AI at Fengchi （GB 20） can improve the patients＇ swallowing function and balance the levels of TXB2 and 6-keto-PGF1α in plasma.目的:证实风池穴注射醒脑静治疗缺血性中风引起的假性延髓麻痹的可行性和有效性。方法:采用单盲、平行、随机对照试验,中风后假性延髓麻痹患者被随机分为两组。对照组患者口服阿司匹林,每日100 mg,连续2星期。治疗组患者在口服阿司匹林的基础上接受风池穴注射醒脑静治疗,每日1次,连续2星期。主要采用洼田饮水实验评价疗效。治疗前后检测血浆中血栓烷素B_2(TXB_2)和6-酮-前列腺素F1α(6-keto-PGF_(1a))水平。结果:治疗组中,患者治疗前后吞咽功能3级以上百分率分别为32%和88%;对照组中分别为28%和76%;两组治疗后差异具有统计学意义(P<0.05)。两组治疗前后血浆TXB_2和6-keto-PGF_(1a)含量与同组治疗前比较,差异均具有统计学意义(均P<0.05);两组治疗后血浆TXB_2和6-keto-PGF_(1a)含量差异均具有统计学意义(均P<0.05)。结论:风池穴注射醒脑静可提高患者的吞咽功能并且能平衡血浆中TXB_2和6-keto-PGF_(1a)水平。

关 键 词：Point  Fengchi （GB 20） HYDRO-ACUPUNCTURE Acupoint Therapy Pseudobulbar Palsy Deglutition Disorders Brain Ischemia Thromboxane B2 

分 类 号：R246.6[医药卫生—针灸推拿学]