抗病毒治疗在HIV感染孕妇母婴阻断中的疗效及安全评估  

Efficacy and safety of antiretroviral therapy to prevent HIV mother to child transmission

作　　者：王瑞[1] 蔡秋娥[1] 陈丽云[1] 李俊芳[1] Wang Rui Cai Qiu ＇ e Chen Liyun Li Junfang.(The Third People＇s Hospital of Shenzhen, Shenzhen 518112, China)

机构地区：[1]深圳市第三人民医院,广东深圳518112

出　　处：《中国艾滋病性病》2017年第2期120-122,共3页Chinese Journal of Aids & STD

基　　金：深圳市卫生计生系统科研项目(201402038)~~

摘　　要：目的探讨抗病毒治疗在艾滋病病毒(HIV)感染孕妇母婴阻断中的疗效性及安全性,为临床IIV感染孕妇母婴阻断治疗提供参考依据。方法收集2010年1月至2016年1月于深圳市第三人民医院分娩的HIV感染孕妇109例,根据不同抗病毒治疗方案将其分为二组:抗病毒治疗组(ART)与对照组(未正规治疗组)。两组新生儿均给予人工喂养。对比两组孕妇分娩情况、新生儿出生情况及HIV感染情况。采用SPSS 19.0软件对数据进行统计分析。结果 ART组共91例,其中86例剖宫产,5例经阴道分娩,新生儿HIV感染率为0,1年存活率为100%;对照组18例均剖宫产分娩,新生儿HIV感染率3/18,1年内2例发生感染HIV死亡,两组孕妇的分娩方式、分娩结局及新生儿HIV感染率,差异有统计学意义(P<0.05);两组新生儿低出生体重率、早产率差异无统计学意义(P>0.05)。109名新生儿无一名出现窒息和畸形。结论 ART在阻断母婴传播中的疗效是显著的,可有效降低胎儿或新生儿的HIV感染率,孕14周后采用ART对胎儿相对安全。Objective To study the efficacy and safety of antiretroviral therapy（ART） to prevent HIV mother to child transmission so as to provide guidance for clinical treatment of pregnant women infected with HIV.Methods109 pregnant women diagnosed with HIV infection from Jan 2010 to Jan 2016 were enrolled in the study,with two groups set up：one receiving ART as treatment group（91 cases） and another without ART as a control group（18 cases） due to refusal of ART during pregnancy and HIV diagnosis at the time of birth.Both of the groups had an artificial feeding to the newborns.Delivery,birth state and HIV/AIDS infection were compared by using SPSS19.0 software.Results Of the treatment group,86 pregnant women got cesarean delivery and 5 had vaginal delivery,with 0%of HIV infection for the neonates,and 100%for 1 year survival.There were 18 pregnant women for cesarean section in control group,with 16.67%（3/18） neonates infected with HIV,and two died of confirmed HIV infection within one year.There was significant difference in the delivery mode,outcomes and HIV infection between the two groups（P〈0.05）,and no significant difference in neonatal low birth weight,and premature birth between the two groups（P〉0.05）.There was no case of asphyxia and malformation among all the 109 neonates.Conclusion ART is effective to reduce HIV mother to child transmission,and it is safe to take ART after mid-trimester of pregnancy.

关 键 词：艾滋病病毒 抗病毒治疗 母婴阻断 低出生体重 早产 

分 类 号：R512.91[医药卫生—内科学]