干扰素和自噬在肿瘤免疫微环境中的研究进展  

Advances in relationships among autophagy,interferons and tumor immunity microenviroment

作　　者：杨文艺[1] 胡镜宙[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海医学硕士研究生200011

出　　处：《医学研究生学报》2017年第3期319-323,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81472516)

摘　　要：自噬是进化上高度保守的细胞代谢途径,具有细胞保护作用。参与肿瘤细胞与机体免疫系统的交互过程而发挥双重效应。干扰素因其抗病毒效应而被熟知,但是其对肿瘤的作用也并非是单纯的抑制作用。干扰素和自噬与肿瘤免疫微环境似乎存在某种联系。文章针对自噬和干扰素与肿瘤免疫微环境的关系和作用进行综述,为抗肿瘤的免疫治疗提供的线索和思路。Autophagy, an evolutionarily conserved catabolic pathway, has the potential to influence the interfaces betweencancer cells and the immune system and plays a dual role on regulation of cancer cells . Interferons, known for its effects on antiviral, do not only exert a suppressive influence on cancer cells. In this respect , there may be certain relationships between autophagy and interferons ,and they may control the tumor microenviroment through interacting with each other. This review will present relationships between autophagy or interferons and tumor immunity microenviroment, and provides clues for anti tumor immunotherapy.

关 键 词：自噬 干扰素 肿瘤免疫微环境 

分 类 号：R392[医药卫生—免疫学]