Optical Brain Imaging： A Powerful Tool for Neuroscience  

作　　者：Xinpei Zhu Yanfang Xia Xuecen Wang Ke Si Wei Gong 

机构地区：[1]Institute of Neuroscience, Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine,Hangzhou 310058, China [2]State Key Laboratory of Modern Optical Instrumentation,College of Optical Science and Engineering and the Collaborative Innovation Center for Brain Science, Zhejiang University, Hangzhou 310027, China

出　　处：《Neuroscience Bulletin》2017年第1期95-102,共8页神经科学通报（英文版）

基　　金：supported by the National Basic Research Development Program(973 Program)of China(2015CB352005);the National Natural Science Foundation of China(6142780065,81527901,and 31571110);Natural Science Foundation of Zhejiang Province of China(Y16F050002);Fundamental Research Funds for the Central Universities of China

摘　　要：As the control center of organisms, the brain remains little understood due to its complexity. Taking advantage of imaging methods, scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods, optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here, we overview several optical imaging techniques in neuroscience of recent years, including brain clearing, the micro-optical sectioning tomography system, and deep tissue imaging.As the control center of organisms, the brain remains little understood due to its complexity. Taking advantage of imaging methods, scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods, optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here, we overview several optical imaging techniques in neuroscience of recent years, including brain clearing, the micro-optical sectioning tomography system, and deep tissue imaging.

关 键 词：Brain imaging Tissue clearing MOSTOptical microscopy Deep tissue imaging 

分 类 号：R338[医药卫生—人体生理学]