Phosphine-mediated enantioselective synthesis of carbocycles and heterocycles  

作　　者：Yu-Ning Gao Min Shi 

机构地区：[1]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Chemical Letters》2017年第3期493-502,共10页中国化学快报（英文版）

基　　金：financial support from the National Basic Research Program of China(973 Project,No.2015CB856603);the National Natural Science Foundation of China(Nos.20472096,21372241,21361140350,20672127,21421091,21372250,21121062,21302203,20732008 and 21572052)

摘　　要：Nucleophilic chiral phosphine catalysis has been prosperous in asymmetric synthesis over the past two decades. Various tunable chiral phosphines display excellent activity and selectivity in asymmetric transformations including acycloaddition reactions and cycloaddition reactions. Enantiomerically enriched cyclic compounds are ubiquitous in natural products and drug molecules. These phosphinecatalyzed reactions provide effective and extensive strategies for the synthesis of a series of complex cyclic compounds as well as the synthesis of chiral compounds which could be easily transformed to carbocycles and heterocycles. This minireview summarizes recent developments in this area and highlights meaningful breakthroughs.Nucleophilic chiral phosphine catalysis has been prosperous in asymmetric synthesis over the past two decades. Various tunable chiral phosphines display excellent activity and selectivity in asymmetric transformations including acycloaddition reactions and cycloaddition reactions. Enantiomerically enriched cyclic compounds are ubiquitous in natural products and drug molecules. These phosphinecatalyzed reactions provide effective and extensive strategies for the synthesis of a series of complex cyclic compounds as well as the synthesis of chiral compounds which could be easily transformed to carbocycles and heterocycles. This minireview summarizes recent developments in this area and highlights meaningful breakthroughs.

关 键 词：Bifunctional phosphines Asymmetric catalysis Carbocycles Heterocycles Cycloaddition reactions 

分 类 号：O621.25[理学—有机化学]