A facile method for building fused quinoxaline-quinolinones via an acidless post-Ugi cascade reaction  

作　　者：Yong Li Jie Lei Jia Xu Dian-Yong Tang Zhong-Zhu Chen Jin Zhua Chuan Xu 

机构地区：[1]Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences [2]Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI,Chongqing University of Arts and Sciences [3]Department of Oncology, Chengdu Military General Hospital

出　　处：《Chinese Chemical Letters》2017年第3期541-545,共5页中国化学快报（英文版）

基　　金：the Chongqing Research Program of Basic Research and Frontier Technology(Nos.cstc2015jcyj A1328 and cstc2015zdcy-ztzx0191);the Scientific Research Foundation of Chongqing University of Arts and Sciences(Nos.R2013XY01 and R2013XY02);Sichuan Provincial Science Fund for Distinguished Young Scholars(No.2015JQO055)

摘　　要：A series of quinolino[3,4-b]quinoxalin-6（5H）-ones have been synthesized using an Ugi/deprotection/cyclization（UDC） strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3,4-b]quinoxalin-6（5H）-ones for high-throughput screening in medicinal chemistry.A series of quinolino[3,4-b]quinoxalin-6（5H）-ones have been synthesized using an Ugi/deprotection/cyclization（UDC） strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3,4-b]quinoxalin-6（5H）-ones for high-throughput screening in medicinal chemistry.

关 键 词：Quinoxaline Quinolino[3 4-b]quinoxalin-6（5H）-one Ugi/deprotection/cyclization（UDC） strategy Nucleophilic substitution reaction One-pot 

分 类 号：O626[理学—有机化学]