Novel chiral multidentate P3N4-type ligand for asymmetric transfer hydrogenation of aromatic ketones  

作　　者：Meng Tao Fang Wu Teng Li Yan-Yun Li Jing-Xing Gao 

机构地区：[1]College of Chemistry and Chemical Engineering, and National Engineering Laboratory for Green Chemical Production of Alcohols-Ethers-Esters,Xiamen University, Xiamen 361005, China

出　　处：《Chinese Chemical Letters》2017年第1期97-100,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (No. 21173176);the Program for Innovative Research Team in Chinese Universities (No. IRT_14R31);the Fundamental Research Funds for the Central Universities (No. 20720150040);NFFTBS (No. J1310024) for financial support

摘　　要：Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS.Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand（R,R,R,R）-3 and IrCl（CO）（PPh3）2exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee.Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS.Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand（R,R,R,R）-3 and IrCl（CO）（PPh3）2exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee.

关 键 词：Chiral aminophosphine ligand Asymmetric catalysis Asymmetric transfer hydrogenation Chiral alcohols Aromatic ketones 

分 类 号：O641.4[理学—物理化学]