Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amines  

作　　者：Santhosh Govindaraju Sumaiya Tabassum Riyaz-ur-Rahaman Khan Mohamed Afzal Pasha 

机构地区：[1]Department of Studies in Chemistry, Central College Campus, Bangalore University, Bengaluru 560001, India

出　　处：《Chinese Chemical Letters》2017年第2期437-441,共5页中国化学快报（英文版）

基　　金：the financial assistance by the VGST, Dept. of IT, BT and Science & Technology, Government of Karnataka for the CESEM Award Grant No. 24 (2010–2011)

摘　　要：Meglumine efficiently catalyzes the one-pot,five-component reaction of hydrazine,ethyl acetoacetate,aryl aldehydes,substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amine derivatives.The present approach offers several advantages such as shorter reaction durations,low cost,excellent yields,milder reaction conditions,simple workup procedure and is environment friendly.All the synthesized derivatives are characterized by IR,^1H NMR,^13C NMR,HRMS and CHN analysis.Meglumine efficiently catalyzes the one-pot,five-component reaction of hydrazine,ethyl acetoacetate,aryl aldehydes,substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amine derivatives.The present approach offers several advantages such as shorter reaction durations,low cost,excellent yields,milder reaction conditions,simple workup procedure and is environment friendly.All the synthesized derivatives are characterized by IR,^1H NMR,^13C NMR,HRMS and CHN analysis.

关 键 词：One-pot five-component reaction Substituted phenylacetonitriles Meglumine Pyrazolopyridin-6-amines Ethanol 

分 类 号：O621.251[理学—有机化学]