Three-component reaction of triphenylphosphine,dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile for diastereoselective synthesis of densely substituted 2,3-dihydrofurans  

作　　者：Wen-Jie Qi Ying Han Chang-Zhou Liu Chao-Guo Yan 

机构地区：[1]College of Chemistry&Chemical Engineering,Yangzhou University,Yangzhou 225002,China

出　　处：《Chinese Chemical Letters》2017年第2期442-445,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21172190);the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：The three-component reaction of triphenylphosphine,dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile in dry methylene dichloride at room temperature resulted in unexpected densely substituted 1-（triphenyl-λ^5-phosphanylidene）ethyl）-2,3-dihydrofurans in satisfactory yields with high diastereoselectivity.The relative configuration of the 2,3-dihydrofurans was elucidated by determination of single crystal structures.The three-component reaction of triphenylphosphine,dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile in dry methylene dichloride at room temperature resulted in unexpected densely substituted 1-（triphenyl-λ^5-phosphanylidene）ethyl）-2,3-dihydrofurans in satisfactory yields with high diastereoselectivity.The relative configuration of the 2,3-dihydrofurans was elucidated by determination of single crystal structures.

关 键 词：Multicomponent reaction Triphenylphosphine But-2-ynedioate Pivaloylacetonitrile 2 3-Dihydrofuran 

分 类 号：O621.3[理学—有机化学] O626[理学—化学]