Theophylline as a new and green catalyst for the one-pot synthesis of spiro[benzo[α]pyrano[2,3-c]phenazine]and benzo[α]pyrano[2,3-c]phenazine derivatives under solvent-free conditions  

作　　者：Afshin Yazdani-Elah-Abadi Malek-Taher Maghsoodlou Razieh Mohebat Reza Heydari 

机构地区：[1]Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran [2]Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

出　　处：《Chinese Chemical Letters》2017年第2期446-452,共7页中国化学快报（英文版）

基　　金：financial support from the Research Council of the University of Sistan and Baluchestan and Islamic Azad University of Yazd

摘　　要：A green,convenient,high yielding and one-pot procedure for the synthesis of novel spiro[benzo[α]pyrano[2,3-c]phenazine]derivatives by domino multi-component condensation reaction between 2-hydroxynaphthalene-l,4-dione,benzene-l,2-diamines,ninhydrine,and malononitrile in the presence of a catalytic amount of 1,3-dimethyl-7H-purine-2,6-dione（theophylline） as an expedient,eco-friendly and reusable solid base catalyst under thermal,microwave irradiation and solvent-free conditions.This procedure has also been applied successfully for the synthesis of benzo[α]pyrano[2,3-c]phenazines.A green,convenient,high yielding and one-pot procedure for the synthesis of novel spiro[benzo[α]pyrano[2,3-c]phenazine]derivatives by domino multi-component condensation reaction between 2-hydroxynaphthalene-l,4-dione,benzene-l,2-diamines,ninhydrine,and malononitrile in the presence of a catalytic amount of 1,3-dimethyl-7H-purine-2,6-dione（theophylline） as an expedient,eco-friendly and reusable solid base catalyst under thermal,microwave irradiation and solvent-free conditions.This procedure has also been applied successfully for the synthesis of benzo[α]pyrano[2,3-c]phenazines.

关 键 词：Multi-component domino reactions（MDRs） Green chemistry Theophylline Spiro[benzo[α]pyrano[2 3-c]phenazine] Benzo[α]pyrano[2 3-c]phenazine 

分 类 号：O643.36[理学—物理化学] TQ463.5[理学—化学]