生物医学光学中NADH荧光检测技术的发展  

Development of NADH Fluorescence Detection Technology in Biomedical Optics

作　　者：张瑞[1] 黄玉广[1] 裴应玫 党昱东 张知[2] 张建保[2] 张镇西[3] ZHANG Ruia HUANG Yuguanga PEI Yingmeia DANG Yudonga ZHANG Zhib ZHANG Jianbaob ZHANG Zhenxic(Xi＇ an Jiaotong University a. The Tenth Group of Comprehensive Pratice Training, School of Life Science ＆ Technolog b. School of Life Science ＆Technolog c. Key Laboratory of Information of Ministry of Education, Institute of Biomadical Analytical Technology ＆ Instrumentation, Xi＇ an 710049, Shaanxi, Chin)

机构地区：[1]西安交通大学生命科学与技术学院综合实践训练第十小组,陕西西安710049 [2]西安交通大学生命科学与技术学院,陕西西安710049 [3]西安交通大学生物医学信息工程教育部重点实验室、生物医学分析技术与仪器研究所,陕西西安710049

出　　处：《激光生物学报》2016年第6期481-490,共10页Acta Laser Biology Sinica

基　　金：国家自然科学基金(11274249)

摘　　要：NADH(还原型烟酰胺腺嘌呤二核苷酸)自1962年被发现至今已有五十多年了,在此期间,运用NADH及其相关技术进行医疗诊断与医学检测的方式不断发展,领域也不断扩大。从当前的研究成果来看,NADH因为其独有的性质在现代医学诊断与检测领域发挥了极大的作用,如实时、无损地监测脑部的活动;清晰、有效地识别不同种类的脑组织;抗细胞辐射损伤;抗辐射诱导的细胞凋亡;进行人体内的诸多平衡调节及人体生物钟调节等。本文将重点介绍在重要领域中的NADH研究和应用的突破。As NADH（ reduced nicotinamide adenine dinucleotide） has been discovered over five decades since 1962,the using of NADH and its technique for medical diagnosis and medical testing methods emerge in an endless stream,the field is also expanding. From the current research results,NADH has played an important role in the field of modern medical diagnosis and detection because of its unique nature. Especially in the area of non-destructively monitoring brain activity in real-time,recognizing different kinds of brain tissue clearly and effectively,resisting cells radiation damage,resisting the apoptosis induced by radiation,regulating many balances in the human body and regulating human body biological clock. This paper will focus on the important areas of the breakthrough in NADH researches and adhibitions.

关 键 词：NADH 荧光检测 生物医学 医疗仪器 

分 类 号：R318.51[医药卫生—生物医学工程]