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作 者:Hao Zhu Lianwan Chen Yihong Yang Zhiwen Zhu Xianliang Zhang Wei Li Long Miao Yan Zhang Guangshuo Ou
机构地区:[1]Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China [2]Institute of Biophysics, Chinese Academy of Sciences, Beijing 100081, China
出 处:《Cell Research》2017年第3期448-451,共4页细胞研究(英文版)
基 金:GO thanks Drs D Huangfu, G Jansen and M Bettencourt Dias for their discussions regarding this project. We also thank the staff members L Xiaomin of Tsinghua University Branch of China Na- tional Center for Protein Sciences (Beijing, China) for providing the facility support. This work was supported by the National Basic Research Program of China (973 Program; 2013CB945600 and 2012CB945002), and the National Natural Science Foundation of China (31201048, 31222035, 31101002, 31100972, 31171295, 31190063 and 31501131).
摘 要:Dear Editor, Cilia are remarkable microtubule (MT)-based organelles that are essential for cell motility, sensory perception and signal transduction [1]. Ciliary defects have been implicated in various human diseases [1]. Although the rod-shaped cilium morphology and the axonemal structure characterized by nine-doublet MTs were described decades ago [2, 3], the molecular regulations of cilium morphology and axonemal structure are still poorly defined.
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