戊酸雌二醇与坤宁安丸对更年期综合征女性激素水平及免疫功能的影响  

Effects of Estradiol Valerate Combined with Kunningan Pill on the Serum Hormones Levels and Immune Function of Patients with Climacteric Syndrome

作　　者：饶云霞 张申华[1] 杨艳华[1] 艾文娟[2] 刘建华[3] 马元玉[4] 

机构地区：[1]天门市第一人民医院(湖北科技学院附属医院)妇产科,湖北天门431700 [2]天门市妇幼保健院妇产科,湖北天门431700 [3]南方医科大学第五附属医院麻醉科,广东广州510000 [4]潍坊市妇幼保健院妇科,山东潍坊261000

出　　处：《现代生物医学进展》2017年第1期119-122,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(SJ970572)

摘　　要：目的:探讨戊酸雌二醇联合坤宁安丸对女性更年期综合征患者血清激素水平及免疫功能影响。方法:收集我院就诊或住院治疗的120例更年期综合征患者,随机分为实验组和对照组,每组60例。对照组患者给予戊酸雌二醇治疗,实验组患者在对照组基础上给予坤宁安丸治疗。分别于治疗前后对患者血清卵泡刺激素(FSH)、雌二醇(E2)、CD3^+、CD4^+、CD8^+水平及Kupperman评分、临床疗效进行检测并比较。结果:与治疗前相比,治疗后两组患者的FSH、CD8^+、KI评分水平均下降(P<0.05),E2、CD3^+CD4^+水平均升高(P<0.05);与对照组相比,实验组患者的FSH、CD8^+、KI评分水平较低(P<0.05),E2、CD3^+、CD4^+水平较高,临床治疗总有效率较高(P<0.05)。结论:戊酸雌二醇联合坤宁安丸能够升高更年期综合征患者血清E2水平,降低FSH水平,并提高患者的免疫功能,临床疗效较好。Objective： To investigate the estradiol valerate combined Kunningan Pill on serum hormone level and immune functions in patients with climacteric syndrome. Methods： 120 cases of menopausal syndrome in our hospital were selected and randomly divided into the experiment group and the control group with 60 cases in each group. The control group were treated with estradiol valerate tablets 1 mg/time, 1 times/d; the patients in the experiment group were given Kunningan Pill based on the control group, 3 g/time, 3times/d, oral. Treatment for 8 consecutive weeks. After the treatment, the serum follicle stimulating hormone（FSH）, estradiol（E2）, CD3＋,CD4＋, CD8＋, Kupperman score and the clinical efficacy of patients were detected and compared. Results： Compared with before treatment, the FSH, CD8＋, Ki score levels decreased（P〈0.05）, E2, CD3＋, CD4＋levels were significantly increased（P〈0.05） after treatment of two groups of patients; compared with the control group, FSH, CD8＋, Ki score levels were lower（P〈0.05）, E2, CD3＋, CD4＋levels were higher, clinical treatment of total efficiency was higher（P〈0.05） Conclusion： Estradiol valerate combined Kunningan Pill can increased menopausal syndrome patients, the level of serum E2, reduce FSH levels, enhance the immune function and the clinical.

关 键 词：戊酸雌二醇 坤宁安丸 更年期综合征 免疫功能 

分 类 号：R711.75[医药卫生—妇产科学]