未足月胎膜早破合并绒毛膜羊膜炎孕妇血清中NE,Ox-AT及IL-8水平变化及临床意义  

Change of Serum NE,Ox-AT and IL-8 in Pregnant Woman with Preterm Premature Rupture of Membranes Combined with Chorioamnionitis and Its Clinical Significance

作　　者：翁廷松 何美玲[2] 刘非 韩田骏 冯绮玲[2] 古聪敏 

机构地区：[1]广州市妇女儿童医疗中心产科,广东广州510120 [2]中山大学孙逸仙纪念医院内分泌血液科,广东广州510120 [3]广州市妇女儿童医疗中心检验科,广东广州510120 [4]广州市妇女儿童医疗中心病理科,广东广州510120

出　　处：《现代生物医学进展》2017年第1期133-136,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨未足月胎膜早破(PPROM)合并绒毛膜羊膜炎(HCA)孕妇血清中中性粒细胞弹性蛋白酶(NE)、氧化型α1-抗胰蛋白酶(Ox-AT)及白细胞介素-8(IL-8)水平变化及对妊娠结局的影响。方法:选择2015年3月至2016年2月我院收治的PPROM孕妇86例,根据患者是否合并HCA分为HCA组(n=46)和非HCA组(n=40),HCA组包括轻度(n=16)、中度(n=15)和重度(n=15),同期选择来我院进行产检的正常孕妇45例作为对照组。应用酶联免疫吸附测定法测定孕妇产前血清NE、Ox-AT及IL-8水平,对比其在不同组孕妇间的差异,分析HCA与PPROM孕妇的妊娠结局的关系。结果:HCA组及非HCA组孕妇血清NE、Ox-AT及IL-8水平均显著高于对照组,且HCA组均显著高于非HCA组,差异均具有统计学意义(P<0.05)。随着HCA的程度加重,孕妇血清中NE、Ox-AT及IL-8水平明显升高,分别与HCA严重程度呈正相关(r=0.732、0.694、0.787;均P<0.05)。HCA组中孕妇产后出血率、剖宫产率及早产儿肺炎率明显高于非HCA组,而Apgar评分显著低于非HCA组,差异均具有统计学意义(P<0.05)。结论:血清NE、Ox-AT及IL-8与PPROM合并HCA孕妇的发生、发展有关,及时检查上述指标有助于改善此类孕妇的妊娠结局。Objective： To investigate the change of neutrophil elastase（NE）, Oxidized α1-antitrypsin（Ox-AT）and interleukin-8（IL-8）in pregnant woman with preterm premature rupture of membranes（PPROM）combined with chorioamnionitis（HCA）and its influence on the pregnancy outcome. Methods： 86 cases of pregnant women with PPROM were selected from March 2015 to February 2016, the women combined with HCA were divided into HCA group（n=46）, the women without HCA were non HCA group（n=40）, and HCA group was divided into mild（n=16）, moderate（n=15）and severe（n=15）. Meanwhile 45 cases of healthy pregnant women underwent antenatal care in our hospital were treated as control group. Levels of serum NE, Ox-AT and IL-8 in prenatal were detected by Enzyme linked immunosorbent assay method, and their difference were compared in different groups, at the same time the relationship of pregnancy outcomes and HCA were analyzed. Results： The level of serum NE, Ox-AT and IL-8 of HCA group and non HCA group were significantly higher than those of control group, and HCA group were significantly higher than those of the non HCA group, which the differences were statistically significant（P〈0.05）. With the increasing of degree of HCA,levels of serum NE, Ox-AT and IL-8 increased significantly（r=0.732, 0.694, 0.787; all P〈0.05）; The postpartum haemorrhage rate,caesarean delivery rate and premature pneumonia rate in HCA group were significantly higher than non HCA group, while Apgar score was significantly lower than non HCA group, and the differences were statistically significant（P〈0.05）. Conclusion： Serum NE,Ox-AT and IL-8 relate to the occurrence and development of pregnant women with PPROM combined with HCA, inspecting the above indicators is helpful to improve pregnancy outcomes in this kind of pregnant women.

关 键 词：未足月胎膜早破 绒毛膜羊膜炎 中性粒细胞弹性蛋白酶 氧化型α1-抗胰蛋白酶 白细胞介素-8 妊娠结局 

分 类 号：Q579.1[生物学—生物化学]