VEGF和IGF-Ⅰ在子宫内膜异位症患者血清中的表达及临床意义  

Expression of VEGF and IGF-I in Serum of Patients with Endometriosis and Their Clinical Significance

作　　者：奈嫚嫚[1] 刘琰[1] 周仲元[1] 徐一鸣[1] 李根霞[1] 

机构地区：[1]郑州大学第三附属医院妇产科,河南郑州450052

出　　处：《现代生物医学进展》2017年第2期342-344,共3页Progress in Modern Biomedicine

摘　　要：目的:探究血管内皮生长因子(VEGF)和胰岛素样生长因子-Ⅰ(IGF-Ⅰ)在子宫内膜异位症患者血清中的表达及临床意义,为子宫内膜异位症的治疗提供参考。方法:选取我院2015年1月至2016年1月收治的子宫内膜异位症患者50例为实验组,另选体检中心健康妇女50例为对照组。实验组患者根据疾病不同分期分为Ⅰ、Ⅱ期(n=24)和Ⅲ、Ⅳ期(n=26)。通过酶联免疫吸附法(ELISA)检测两组对象血清中VEGF和IGF-Ⅰ的水平,采用Pearson相关分析法分析实验组患者血清中VEGF和IGF-Ⅰ表达的相关性。结果:实验组患者血清中VEGF和IGF-Ⅰ的水平均明显高于对照组,差异有统计学意义(P<0.05);实验组Ⅲ、Ⅳ期患者血清中VEGF和IGF-Ⅰ的水平明显高于Ⅰ、Ⅱ期患者,差异有统计学意义(P<0.05);Pearson相关性分析显示实验组患者血清中VEGF和IGF-Ⅰ的水平变化呈正相关关系(r=0.507,P<0.05)。结论:子宫内膜异位症患者血清中VEGF和IGF-Ⅰ的水平高于正常水平,并随着病情的加重而不断升高,且二者呈正相关关系,可协同作用加快病情发展。Objective：To explore the vascular endothelial growth factor（VEGF）and insulin like growth factor Ⅰ（IGF-Ⅰ）in serum of patients with endometriosis and their clinical significance, and to provide reference for the treatment of endometriosis. Methods： Selected50 cases of patients with endometriosis who were treated in our hospital from January 2015 to January 2016 as the experimental group,and selected 50 healthy physical examination people as the control group in the same period. The patients in the experimental group were divided into Ⅰ, Ⅱ stage（n=24） and Ⅲ, Ⅳ stage（n=26） by the different stages of the disease. Detected the levels of VEGF and IGF-Ⅰ in serum of objects in two groups by enzyme-linked immunosorbent assay（ELISA）, analyzed the correlation of VEGF and IGF-Ⅰ expression in the experimental group by Pearson correlation analysis. Results： The levels of VEGF and IGF-Ⅰ in the serum of the experimental group were significantly higher than those in the control group, the differences were statistically significant（P〈0.05）; The levels of VEGF and IGF-Ⅰ in the serum of the experimental group were significantly higher than that in the control group, the difference was statistically significant（P〈0.05）; The levels of VEGF and IGF-Ⅰ in serum of patients with Ⅳ and Ⅲ stage in the experimental group were significantly higher than that with Ⅰ and Ⅱ stage, the difference was statistically significant（P〈0.05）; Pearson correlation analysis showed that the levels of VEGF and IGF-Ⅰ in serum of patients in the experimental group were positively correlated（r=0.507, P〈0.05）. Conclusion： The levels of VEGF and IGF-Ⅰ in serum of patients with endometriosis is higher than normal level, and increase with the aggravation of the disease,and the two had a positive correlation, which is able to accelerate the development of the disease.

关 键 词：VEGF IGF-Ⅰ 子宫内膜异位症 临床意义 

分 类 号：R711.71[医药卫生—妇产科学]