心血管病患者并发肺部感染的病原菌分布及危险因素分析  

Pathogenic Bacteria Distribution and Risk Factors of Pulmonary Infection in Patients with Cardiovascular Disease

作　　者：魏伟[1] 张洁[1] 于振宇[1] 殷令妮[1] 陈德宣 

机构地区：[1]上海交通大学医学院附属仁济医院嘉定分院/上海市嘉定区中心医院老年病科,上海201800

出　　处：《现代生物医学进展》2017年第3期507-509,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨心血管病患者并发肺部感染的病原菌分布特点及相关危险因素,以降低感染率。方法:选择2015年8月~2016年3月因心血管病入院治疗的154例患者为研究对象,收集其相关临床数据,进行回顾性分析,采集医院感染患者痰标本进行细菌培养,分析病原菌分布及危险因素。结果:154例心血管病患者并发肺部感染者25例,感染率为16.23%。共培养出病原菌27株,革兰阴性菌16株(占59.26%)、革兰阳性菌7株(占25.93%)及真菌4株(占14.81%)。单因素分析显示年龄、基础疾病、侵入性操作、抗生素使用、住院时间等与医院感染率有关,差异有统计学意义(P<0.05);logistic回归分析发现,年龄(≥60岁)、有基础疾病、有侵入性操作、使用抗生素、住院时间(>14天)是心血管病患者并发肺部感染的危险因素。结论:心血管病患者肺部感染的主要病原菌为大肠埃希菌、肺炎克雷伯菌以及金黄色葡萄球菌等,应针对相关危险因素进行干预,以降低医院感染率。Objective： To investigate the pathogenic bacteria distribution characteristics and associated risk factors of pulmonary infection in patients with cardiovascular disease in order to reduce the infection rate. Methods： From August 2015 to March 2016,154 patients admitted to hospital because of cardiovascular disease were selected,the date of patients were collected and analyzed retrospectively.Sputum samples of patients with hospital infection were collected for bacterial culture,and distribution and risk factors of pathogenic bacteria were analysis. Results： patients with pulmonary infection in 154 cases of patients with cardiovascular disease had 27 cases,the incidence rate was 16.23. There were 27 strains of pathogenic bacteria,including 16 strains of gram negative bacteria（59.26%）,7 strains of gram positive bacteria（25.93%）and 4 strains of fungi（14.81%）. Single factor analysis showed that age,basic diseases,invasive operation,length of hospital stay,antibiotic use and other were related to hospital infection rate,the differences were statistically significant（P〈0.05）; Logistic regression analysis found that age（≥60years）,wtih basic diseases,with invasive operation,used antibiotic,length of hospital stay（〉14d）were risk factors for cardiovascular disease complicated with lung infection. Conclusion： The main pathogenic bacteria of cardiovascular disease complicated with pulmonary infection are escherichia coli,klebsiella pneumoniae,staphylococcus aureus,etc,related intervene should be aimed at risk factors,in order to reduce hospital infection rates.

关 键 词：心血管病 肺部感染 危险因素 预防措施 

分 类 号：R54[医药卫生—心血管疾病] R563[医药卫生—内科学]