代谢组学在一氧化碳中毒研究的应用和展望  

Application and Prospects of Metabolomics in the Study of Carbon Monoxide Poisoning

作　　者：周磊[1] 范茂丹[1] 郑成刚[2] 衣洪杰[2] 刘青乐[2] 

机构地区：[1]南京军区杭州疗养院海勤疗养区,浙江杭州310002 [2]第二军医大学附属长海医院高压氧治疗科,上海200433

出　　处：《现代生物医学进展》2017年第3期572-574,592,共4页Progress in Modern Biomedicine

基　　金：杭州市医药卫生科研基金项目(20150133x05)

摘　　要：一氧化碳中毒是常见的以中枢神经系统损害为主的全身性疾病。一氧化碳作为一个脂溶性分子,进入细胞内造成组织缺氧。一氧化碳是否可以诱导产生其他特定的生物学效应,还需要我们去研究。代谢组学是继基因组学、转录组学、蛋白质组学后的又一新兴学科,在肿瘤、糖尿病、冠心病、肥胖症、脑卒中等多种临床疾病的相关研究中显示出巨大的潜力。将代谢组学技术应用到一氧化碳中毒研究中,可以加深对一氧化碳中毒发病机制的认识,丰富早期诊断方法,改善治疗效果的监测手段。但代谢组学技术在一氧化碳中毒研究中的应用仍是凤毛麟角,我们在此对代谢组学在一氧化碳中毒研究中应用及前景作一展望。Carbon monoxide poisoning was a systemic disease which mainly damaged the central nervous system. Carbon monoxide entered cells as a fat-soluble molecule which caused tissue hypoxia. If carbon monoxide could cause other biological effects awaited us to research. Metabolomics was a up-and-coming subject following genomics,transcriptomics,proteomics,which showed great potential in the research of a variety of clinical disease,such as cancer,diabetes,coronary heart disease,obesity,stroke. We could deepen our understanding of the pathogenesis,improve the early diagnosis,and enrich the monitoring means of the effects of treatments to carbon monoxide poisoning by appling metabolomics to the studies of carbon monoxide poisoning. But the application of metabolomics technique in the studies of carbon monoxide poisoning was rare. Its role and research prospects in the research of carbon monoxide poisoning were looked forward as follows.

关 键 词：代谢组学 高压氧 一氧化碳中毒 

分 类 号：R595.1[医药卫生—内科学]