SUMO化在配子中的研究进展  

The research development of SUMOylation in gamete

作　　者：姜泽[1] 金一[1] 

机构地区：[1]延边大学农学院动物科学系,吉林延吉133000

出　　处：《黑龙江畜牧兽医》2017年第3期46-48,52,共4页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(31260529)

摘　　要：小类泛素(small ubiquitin-related modifier,SUMO)属于类泛素蛋白的一种,其种类多种多样,在哺乳动物体内主要有三种亚型的SUMO:SUMO1、SUMO2和SUMO3。SUMO化修饰作为一种重要的蛋白翻译后修饰方式,参与了转录调节、核转运、维持基因组完整性及信号转导等一系列生理过程的调控。然而,它在人类精子功能中的作用还没有被鉴定出来。现从分类、结构、生物学功能及在精子中的相关研究介绍SUMO化。SUMO, smaU ubiquitin - related modlfier,is a kind of ubiquitin proteins. It has a lot of varieties, there are three major subtypes of SUMO ：SUMO1 ,SUM02 and SUM03. As an important post -translational modification of proteins, SUMOylation have been reported to involved in regulating a range of physiological processes including transcriptional regulation,nuclear transport,maintaining integrity of the genomic and signal transduction, etc. However, its role in the function of human sperm has not yet been identified. The paper will introduce SUMOylation from classification, structure, biological function and the related researches in sperm.

关 键 词：SUMO 精子 类泛素化 冗余核膜 泛素 免疫印迹分析 

分 类 号：R977.6[医药卫生—药品]