血清25-羟维生素D与过敏性紫癜发病风险关系的病例对照研究  

A case-control study on the relationship between serum 25-hydroxy vitamin D and the risk of Henoch-Schonlein purpura

作　　者：董显燕[1] 钟涛[1] 黄郁波[1] 易玲[1] 曾海江[1] 钟小梅[1] 

机构地区：[1]江西省赣州市人民医院/南昌大学附属赣州医院儿科,341000

出　　处：《重庆医学》2017年第8期1076-1078,1081,共4页Chongqing medicine

摘　　要：目的探讨人体血清25-羟维生素D[25(OH)D]与过敏性紫癜(HSP)发病风险的关系。方法采用酶联免疫吸附法检测53例HSP患者和161例随机对照儿童血清25(OH)D水平,并采用调查问卷收集研究对象基本资料。以214例研究对象的25(OH)D水平四分位数为依据将其分为4个区间,用Logistic回归模型评价各区间血清25(OH)D水平与HSP发病风险的关联程度。结果病例组血清25(OH)D水平中位数为11.40ng/mL,对照组为15.36ng/mL,两组差异有统计学意义(P<0.05)。以最低浓度组即第1区间为参考水平,第2、3、4区间OR值及95%CI分别为0.468(0.341~0.771)、0.442(0.302~0.627)、0.339(0.199~0.501)。采用前进法对性别、抽血季节进行校正,校正后第2、3、4区间OR值及95%CI分别为0.459(0.333~0.741)、0.408(0.317~0.611)、0.387(0.221~0.517),25(OH)D水平的升高与HSP发病风险的下降存在线性相关(P<0.05)。结论 HSP发病风险随血清25(OH)D水平的增高而降低,25(OH)D可能是HSP发病的一项保护因素。Objective To explore the relationship between serum 25-hydroxy vitamin D [25（OH）D]concentrations and the risk of Henoch-Schonlein purpura（HSP）.Methods A case control study was designed.Serum 25（OH）D concentrations were measured by radioimmunoassay in 214 participants,including 53 HSP patients and 161status-matched healthy controls.Information concerning demographic data,genetic,background,and environmental exposures was collected using questionnaire.The study participants were divided into four groups according to quartile range of 25（OH）D concentration and logistic regression modeling was used to evaluate the relation with HSP risk by estimating odds ratios（OR）and 95%confidence intervals（CI）.Results The HSP group had a significantly lower concentration of 25（OH）D than the control group（the median in the HSP group was 11.4ng/mL;controls：15.36ng/mL,P〈0.05）.When the first interval was set as the reference level,the OR（95%CI）of the second,third,and fourth intervals were：0.468（0.341-0.771）,0.442（0.302-0.627）,0.339（0.199-0.501）.After adjusting the analysis for the presence of pathogenic related confounding fact OR,the OR（95%CI）of the second,third,and fourth intervals were：0.459（0.333-0.741）,0.408（0.317-0.611）,0.387（0.221-0.517）.The 25（OH）D level was inversely correlated with the risk of HSP（P〈0.05）.Conclusion The risk of HSP was decreased with the increase of serum 25（OH）D concentration,25（OH）D may be a protection factor in the pathogenesis of HSP.

关 键 词：紫癜 过敏性 25-羟维生素D 病例对照研究 

分 类 号：R725.5[医药卫生—儿科]