泌乳素——女性肝郁证一个潜在的生物表征物  

Prolactin: A potential molecular marker of TCM pattern of liver depression in women

作　　者：张媛凤 谢鸣[1] 钱梦[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《北京中医药大学学报》2017年第2期98-102,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.81173193)

摘　　要：肝郁证是中医临床常见的证候之一,对其现代病生理学内涵的认识仍处于探索之中。试图以中医肝郁证的病机及临床特点、肝郁证主要涉及的女性生殖系统疾病的病理生理、泌乳素(PRL)最新研究成果为背景,在搜集有关PRL-肝郁证-关联女性疾病的临床观察和实验研究方面文献基础上,通过整理分析以探查女性肝郁证的分子生物学内涵。结果显示,女性肝郁证及其所涉及的主要疾病和各种雌性肝郁模型动物均伴有体内PRL的异常表达,中医疏肝类方药可以降低其异常升高的PRL,表明女性肝郁与PRL相关。由此作者提出PRL有可能成为女性肝郁证的现代分子靶标的推测,冀为在分子层面揭示中医肝郁证的现代内涵提供重要线索。Pattern of liver depression, a very common TCM pattern in patients especially in female patients, whose pathophysiological connotation in modern society is still to be explored. This paper attempts to find out the modern molecular mechanism of pattern of liver depression in women, based on the pathogenesis and clinical characteristics of the pattern, on the pathophysiological changes of female reproduc- tive diseases related to the pattern and on the latest research findings/of prolactin, combined with retrieving the literature of clinical or animal experiment related to prolactin-pattern-female diseases. The abnormal expression of prolactin can be found in diseases related to pattern of liver depression in women and all female animal model with pattern of liver depression, furthermore, TCM formula guided by the principle of soothing the liver could inhibit the overexpression of prolactin. As the result, the author proposes that prolactin has exact correlation with pattern of liver depression in women, and prolactin may be the novel target molecule of the pattern. The author expects that the clues could help to reveal the molecular mechanism of pattern of liver depression in women.

关 键 词：肝郁证 女性疾病 泌乳素 分子靶标 

分 类 号：R2-03[医药卫生—中医学]