胰岛素增强子结合蛋白-1(ISL1)与肿瘤的发生与发展  

ISL1 in Tumorigenesis and Development

作　　者：石琼[1] 王卫平[2] 

机构地区：[1]云南省肿瘤医院,昆明医科大学第三附属医院检验科,昆明650118 [2]北京大学医学部生物化学与分子生物学系,北京100083

出　　处：《中国生物化学与分子生物学报》2017年第3期242-246,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81472022,No.81071675)资助~~

摘　　要：在人类发育过程中,胰岛素增强子结合蛋白-1(ISL1)被认为是一个胚胎性基因。成年后,ISL1只在特定的组织或器官中表达,例如胰腺和大脑。近年来,在多种肿瘤中检测到ISL1的异常表达,不仅在胰腺内分泌肿瘤、神经肿瘤中高表达(与之相应的正常组织也表达ISL1),而且在淋巴瘤、胃癌和膀胱癌等肿瘤组织中呈现表达(其正常组织不表达ISL1)。ISL1的异常表达可能与肿瘤的发生发展及预后相关。本文针对ISL1与肿瘤的相关性以及在肿瘤发生发展中的功能进行综述,为进一步的分子机制研究提供理论依据。Insulin gene enhancer binding protein-1（ ISL1） is considered as an embryonic gene in the process of human development. In adult,ISL1 is only expressed in specific tissues or organs,such as pancreas and brain. Recent studies have been reported that ISL1 expression was detected in a variety of tumors,including pancreatic endocrine tumors,nerve tumors（ ISL1 can be expressed in corresponding normal tissues）,gastric cancer and bladder cancer. Abnormal expression of ISL1 is often associated with the development and prognosis of diseases. This review summarized the correlation of ISL1 and cancer and the function of ISL1 in tumor occurrence and development,aiming to provide a theoretical basis for further study of the molecular mechanisms.

关 键 词：胰岛素增强子结合蛋白-1 异常表达 肿瘤 

分 类 号：Q291[生物学—细胞生物学]